NDUFB8

From Wikipedia, the free encyclopedia
Jump to: navigation, search
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
Identifiers
Symbols NDUFB8 ; ASHI; CI-ASHI
External IDs OMIM602140 MGI1914514 HomoloGene3668 GeneCards: NDUFB8 Gene
RNA expression pattern
PBB GE NDUFB8 201227 s at tn.png
PBB GE NDUFB8 201226 at tn.png
PBB GE NDUFB8 214241 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4714 67264
Ensembl ENSG00000166136 ENSMUSG00000025204
UniProt O95169 Q9D6J5
RefSeq (mRNA) NM_001284367 NM_026061
RefSeq (protein) NP_001271296 NP_080337
Location (UCSC) Chr 10:
102.27 – 102.29 Mb
Chr 19:
44.55 – 44.56 Mb
PubMed search [1] [2]

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial is an enzyme that in humans is encoded by the NDUFB8 gene.[1][2]


Model organisms[edit]

Model organisms have been used in the study of NDUFB8 function. A conditional knockout mouse line called Ndufb8tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute [3]. Male and female animals underwent a standardized phenotypic screen[4] to determine the effects of deletion.[5][6][7][8] Additional screens performed: - In-depth immunological phenotyping[9]




References[edit]

  1. ^ Emahazion T, Brookes AJ (Nov 1998). "Mapping of the NDUFA2, NDUFA6, NDUFA7, NDUFB8, and NDUFS8 electron transport chain genes by intron based radiation hybrid mapping". Cytogenet Cell Genet 82 (1–2): 114. doi:10.1159/000015081. PMID 9763676. 
  2. ^ "Entrez Gene: NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa". 
  3. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. 
  4. ^ a b "International Mouse Phenotyping Consortium". 
  5. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V et al. (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750. 
  6. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  7. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  8. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN et al. (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMID 23870131. 
  9. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 


Further reading[edit]