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NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
Symbols NDUFS2 ; CI-49
External IDs OMIM602985 MGI2385112 HomoloGene56659 ChEMBL: 3039 GeneCards: NDUFS2 Gene
EC number,
RNA expression pattern
PBB GE NDUFS2 201966 at tn.png
More reference expression data
Species Human Mouse
Entrez 4720 226646
Ensembl ENSG00000158864 ENSMUSG00000013593
UniProt O75306 Q91WD5
RefSeq (mRNA) NM_001166159 NM_153064
RefSeq (protein) NP_001159631 NP_694704
Location (UCSC) Chr 1:
161.17 – 161.18 Mb
Chr 1:
171.23 – 171.25 Mb
PubMed search [1] [2]

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial also known as NADH-ubiquinone oxidoreductase 49 kDa subunit is an enzyme that in humans is encoded by the NDUFS2 gene.[1][2][3]


Mitochondrial complex I is the first multimeric complex of the respiratory chain that catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mammalian mitochondrial complex I is an assembly of at least 43 different subunits. Seven of the subunits are encoded by the mitochondrial genome; the remainder are the products of nuclear genes. The iron-sulfur protein (IP) fraction of complex I is made up of 7 subunits, including NDUFS2.[3]

See also[edit]


  1. ^ Fearnley IM, Finel M, Skehel JM, Walker JE (Oct 1991). "NADH:ubiquinone oxidoreductase from bovine heart mitochondria. cDNA sequences of the import precursors of the nuclear-encoded 39 kDa and 42 kDa subunits". Biochem J. 278. ( Pt 3): 821–9. PMC 1151420. PMID 1832859. 
  2. ^ Procaccio V, de Sury R, Martinez P, Depetris D, Rabilloud T, Soularue P, Lunardi J, Issartel J (Jun 1998). "Mapping to 1q23 of the human gene (NDUFS2) encoding the 49-kDa subunit of the mitochondrial respiratory Complex I and immunodetection of the mature protein in mitochondria". Mamm Genome 9 (6): 482–4. doi:10.1007/s003359900803. PMID 9585441. 
  3. ^ a b "Entrez Gene: NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)". 

Further reading[edit]