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Neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Protein NEDD4 PDB 2KPZ.png
Rendering based on PDB 2KPZ.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NEDD4 ; NEDD4-1; RPF1
External IDs OMIM602278 MGI97297 HomoloGene136740 GeneCards: NEDD4 Gene
EC number 6.3.2.-
RNA expression pattern
PBB GE NEDD4 213012 at tn.png
More reference expression data
Species Human Mouse
Entrez 4734 17999
Ensembl ENSG00000069869 ENSMUSG00000032216
UniProt P46934 P46935
RefSeq (mRNA) NM_001284338 NM_010890
RefSeq (protein) NP_001271267 NP_035020
Location (UCSC) Chr 15:
56.12 – 56.29 Mb
Chr 9:
72.66 – 72.75 Mb
PubMed search [1] [2]

E3 ubiquitin-protein ligase NEDD4 also known as neural precursor cell expressed developmentally down-regulated protein 4 (NEDD-4) is an enzyme that in humans is encoded by the NEDD4 gene.[1][2] NEDD4 has been shown to ubiquitinate and therefore down regulate the epithelial sodium channel (ENaC) in the collecting ducts of the kidneys, therefore opposing the actions of aldosterone and increasing salt excretion. In Liddle's Syndrome NEDD4 is unable to bind to the ENaC and lead to salt retention and hypertension occur.

See also[edit]

Liddle's syndrome


  1. ^ Kumar S, Harvey KF, Kinoshita M, Copeland NG, Noda M, Jenkins NA (May 1997). "cDNA cloning, expression analysis, and mapping of the mouse Nedd4 gene". Genomics 40 (3): 435–43. doi:10.1006/geno.1996.4582. PMID 9073511. 
  2. ^ Imhof MO, McDonnell DP (Jul 1996). "Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors". Mol Cell Biol 16 (6): 2594–605. PMC 231250. PMID 8649367. 

Further reading[edit]