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Neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Protein NEDD4L PDB 1wr3.png
PDB rendering based on 1wr3.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NEDD4L ; NEDD4-2; NEDD4.2; RSP5; hNEDD4-2
External IDs OMIM606384 MGI1933754 HomoloGene86986 GeneCards: NEDD4L Gene
EC number 6.3.2.-
Species Human Mouse
Entrez 23327 83814
Ensembl ENSG00000049759 ENSMUSG00000024589
UniProt Q96PU5 Q8CFI0
RefSeq (mRNA) NM_001144964 NM_001114386
RefSeq (protein) NP_001138436 NP_001107858
Location (UCSC) Chr 18:
55.71 – 56.07 Mb
Chr 18:
64.89 – 65.22 Mb
PubMed search [1] [2]

E3 ubiquitin-protein ligase NEDD4-like is an enzyme that in humans is encoded by the NEDD4L gene.[1][2][3][4]


NEDD4L has been shown to interact with SCNN1A.[2][5]


  1. ^ Erdeniz N, Rothstein R (Jan 2000). "Rsp5, a Ubiquitin-Protein Ligase, Is Involved in Degradation of the Single-Stranded-DNA Binding Protein Rfa1 in Saccharomyces cerevisiae". Mol Cell Biol 20 (1): 224–32. doi:10.1128/MCB.20.1.224-232.2000. PMC 85078. PMID 10594025. 
  2. ^ a b Harvey KF, Dinudom A, Cook DI, Kumar S (May 2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel". J Biol Chem 276 (11): 8597–601. doi:10.1074/jbc.C000906200. PMID 11244092. 
  3. ^ Raikwar NS, Thomas CP (May 2008). "Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel". Am J Physiol Renal Physiol 294 (5): F1157–65. doi:10.1152/ajprenal.00339.2007. PMC 2424110. PMID 18322022. 
  4. ^ "Entrez Gene: NEDD4L Neural precursor cell expressed, developmentally down-regulated 4-like". 
  5. ^ Malbert-Colas, Laurence; Nicolas Gaël; Galand Colette; Lecomte Marie-Christine; Dhermy Didier (Jul 2003). "Identification of new partners of the epithelial sodium channel alpha subunit". C. R. Biol. (France) 326 (7): 615–24. doi:10.1016/s1631-0691(03)00154-9. ISSN 1631-0691. PMID 14556380. 

Further reading[edit]