NEFA (drug)

From Wikipedia, the free encyclopedia
Jump to: navigation, search
NEFA (drug)
NEFA.svg
Systematic (IUPAC) name
(4aR,9aS)-N-Ethyl-4,4a,9,9a-tetrahydro-1H-fluoren-4a-amine
Clinical data
Legal status
?
Identifiers
ATC code ?
Chemical data
Formula C15H19N 
Mol. mass 213.3181 g/mol
 YesY (what is this?)  (verify)

NEFA is a moderate affinity NMDA antagonist (IC50 = 0.51 μM). It is a structural analog of phencyclidine.[1] It was first synthesized by a team at Parke Davis in the late 1950s.[2]

References[edit]

  1. ^ Dilmore JG, Johnson JW (1998). "Open channel block and alteration of N-methyl-D-aspartic acid receptor gating by an analog of phencyclidine". Biophysical Journal 75 (4): 1801–16. doi:10.1016/S0006-3495(98)77622-2. PMC 1299852. PMID 9746522. 
  2. ^ GB Patent 893920 - Polycyclic amino compounds and methods for their production