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Neuronal growth regulator 1
Symbols NEGR1 ; DMML2433; IGLON4; KILON; Ntra
External IDs OMIM613173 MGI2444846 HomoloGene41447 GeneCards: NEGR1 Gene
Species Human Mouse
Entrez 257194 320840
Ensembl ENSG00000172260 ENSMUSG00000040037
UniProt Q7Z3B1 Q80Z24
RefSeq (mRNA) NM_173808 NM_001039094
RefSeq (protein) NP_776169 NP_001034183
Location (UCSC) Chr 1:
71.86 – 72.75 Mb
Chr 3:
156.56 – 157.32 Mb
PubMed search [1] [2]

Neuronal growth regulator 1 also known as NEGR1 is a protein which in humans is encoded by the NEGR1 gene.[1]

Clinical significance[edit]

Variants of the NEGR1 gene may be associated with obesity.[2][3][4]


  1. ^ Funatsu N, Miyata S, Kumanogoh H, Shigeta M, Hamada K, Endo Y, Sokawa Y, Maekawa S (March 1999). "Characterization of a novel rat brain glycosylphosphatidylinositol-anchored protein (Kilon), a member of the IgLON cell adhesion molecule family". J. Biol. Chem. 274 (12): 8224–30. doi:10.1074/jbc.274.12.8224. PMID 10075727. 
  2. ^ Thorleifsson G, Walters GB, Gudbjartsson DF, et al. (January 2009). "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.". Nat. Genet. 41 (1): 18–24. doi:10.1038/ng.274. PMID 19079260. 
  3. ^ Willer CJ, Speliotes EK, Loos RJ, et al. (January 2009). "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation". Nat. Genet. 41 (1): 24–34. doi:10.1038/ng.287. PMC 2695662. PMID 19079261. 
  4. ^ Zhao J, Bradfield JP, Li M, et al. (May 2009). "The role of obesity-associated loci identified in genome wide association studies in the determination of pediatric BMI". Obesity (Silver Spring) 17 (12): 2254–7. doi:10.1038/oby.2009.159. PMC 2860782. PMID 19478790. 

Further reading[edit]