NEIL1

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Nei endonuclease VIII-like 1 (E. coli)
Protein NEIL1 PDB 1tdh.png
PDB rendering based on 1tdh.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NEIL1 ; FPG1; NEI1; hFPG1
External IDs OMIM608844 MGI1920024 HomoloGene11616 GeneCards: NEIL1 Gene
EC number 4.2.99.18
RNA expression pattern
PBB GE NEIL1 219396 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 79661 72774
Ensembl ENSG00000140398 ENSMUSG00000032298
UniProt Q96FI4 Q8K4Q6
RefSeq (mRNA) NM_001256552 NM_028347
RefSeq (protein) NP_001243481 NP_082623
Location (UCSC) Chr 15:
75.64 – 75.65 Mb
Chr 9:
57.14 – 57.15 Mb
PubMed search [1] [2]

Endonuclease VIII-like 1 is an enzyme that in humans is encoded by the NEIL1 gene.[1][2]

NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002).[supplied by OMIM][2]

References[edit]

  1. ^ Hazra TK, Izumi T, Boldogh I, Imhoff B, Kow YW, Jaruga P, Dizdaroglu M, Mitra S (Mar 2002). "Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA". Proc Natl Acad Sci U S A 99 (6): 3523–8. doi:10.1073/pnas.062053799. PMC 122556. PMID 11904416. 
  2. ^ a b "Entrez Gene: NEIL1 nei endonuclease VIII-like 1 (E. coli)". 

Further reading[edit]