NEK9

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NIMA-related kinase 9
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NEK9 ; NERCC; NERCC1; Nek8
External IDs OMIM609798 MGI2387995 HomoloGene13222 ChEMBL: 5257 GeneCards: NEK9 Gene
EC number 2.7.11.1
RNA expression pattern
PBB GE NEK9 212299 at tn.png
PBB GE NEK9 214738 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 91754 217718
Ensembl ENSG00000119638 ENSMUSG00000034290
UniProt Q8TD19 Q8K1R7
RefSeq (mRNA) NM_033116 NM_145138
RefSeq (protein) NP_149107 NP_660120
Location (UCSC) Chr 14:
75.55 – 75.59 Mb
Chr 12:
85.3 – 85.34 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase Nek9 is an enzyme that in humans is encoded by the NEK9 gene.[1][2]


Interactions[edit]

NEK9 has been shown to interact with Structure specific recognition protein 1,[3] NEK6[4][5][6] and Ran (biology).[6]

References[edit]

  1. ^ Holland PM, Milne A, Garka K, Johnson RS, Willis C, Sims JE, Rauch CT, Bird TA, Virca GD (Apr 2002). "Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2". J Biol Chem 277 (18): 16229–40. doi:10.1074/jbc.M108662200. PMID 11864968. 
  2. ^ "Entrez Gene: NEK9 NIMA (never in mitosis gene a)- related kinase 9". 
  3. ^ Tan, Bertrand Chin-Ming; Lee Sheng-Chung (Mar 2004). "Nek9, a novel FACT-associated protein, modulates interphase progression". J. Biol. Chem. (United States) 279 (10): 9321–30. doi:10.1074/jbc.M311477200. ISSN 0021-9258. PMID 14660563. 
  4. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  5. ^ Belham, Christopher; Roig Joan, Caldwell Jennifer A, Aoyama Yumi, Kemp Bruce E, Comb Michael, Avruch Joseph (Sep 2003). "A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases". J. Biol. Chem. (United States) 278 (37): 34897–909. doi:10.1074/jbc.M303663200. ISSN 0021-9258. PMID 12840024. 
  6. ^ a b Roig, Joan; Mikhailov Alexei, Belham Christopher, Avruch Joseph (Jul 2002). "Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression". Genes Dev. (United States) 16 (13): 1640–58. doi:10.1101/gad.972202. ISSN 0890-9369. PMC 186374. PMID 12101123. 

Further reading[edit]