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NIMA-related kinase 9
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NEK9 ; NERCC; NERCC1; Nek8
External IDs OMIM609798 MGI2387995 HomoloGene13222 IUPHAR: 2124 ChEMBL: 5257 GeneCards: NEK9 Gene
EC number
RNA expression pattern
PBB GE NEK9 212299 at tn.png
PBB GE NEK9 214738 s at tn.png
More reference expression data
Species Human Mouse
Entrez 91754 217718
Ensembl ENSG00000119638 ENSMUSG00000034290
UniProt Q8TD19 Q8K1R7
RefSeq (mRNA) NM_033116 NM_145138
RefSeq (protein) NP_149107 NP_660120
Location (UCSC) Chr 14:
75.55 – 75.59 Mb
Chr 12:
85.3 – 85.34 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase Nek9 is an enzyme that in humans is encoded by the NEK9 gene.[1][2]


NEK9 has been shown to interact with:


  1. ^ Holland PM, Milne A, Garka K, Johnson RS, Willis C, Sims JE et al. (Apr 2002). "Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2". J Biol Chem 277 (18): 16229–40. doi:10.1074/jbc.M108662200. PMID 11864968. 
  2. ^ "Entrez Gene: NEK9 NIMA (never in mitosis gene a)- related kinase 9". 
  3. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  4. ^ Belham C, Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M et al. (Sep 2003). "A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases". J. Biol. Chem. 278 (37): 34897–909. doi:10.1074/jbc.M303663200. PMID 12840024. 
  5. ^ a b Roig J, Mikhailov A, Belham C, Avruch J (Jul 2002). "Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression". Genes Dev. 16 (13): 1640–58. doi:10.1101/gad.972202. PMC 186374. PMID 12101123. 
  6. ^ Tan BC, Lee SC (Mar 2004). "Nek9, a novel FACT-associated protein, modulates interphase progression". J. Biol. Chem. 279 (10): 9321–30. doi:10.1074/jbc.M311477200. PMID 14660563. 

Further reading[edit]