NEUROD2

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Neuronal differentiation 2
Identifiers
Symbols NEUROD2 ; NDRF; bHLHa1
External IDs OMIM601725 MGI107755 HomoloGene4489 GeneCards: NEUROD2 Gene
RNA expression pattern
PBB GE NEUROD2 210271 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4761 18013
Ensembl ENSG00000171532 ENSMUSG00000038255
UniProt Q15784 Q62414
RefSeq (mRNA) NM_006160 NM_010895
RefSeq (protein) NP_006151 NP_035025
Location (UCSC) Chr 17:
37.76 – 37.77 Mb
Chr 11:
98.33 – 98.33 Mb
PubMed search [1] [2]

Neurogenic differentiation factor 2 is a protein that in humans is encoded by the NEUROD2 gene.[1][2]

This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.[2]

Interactions[edit]

NEUROD2 has been shown to interact with Protein kinase N1.[3]

References[edit]

  1. ^ Tamimi RM, Steingrimsson E, Montgomery-Dyer K, Copeland NG, Jenkins NA, Tapscott SJ (Apr 1997). "NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively". Genomics 40 (2): 355–7. doi:10.1006/geno.1996.4578. PMID 9119405. 
  2. ^ a b "Entrez Gene: NEUROD2 neurogenic differentiation 2". 
  3. ^ Shibata, H; Oda H; Mukai H; Oishi K; Misaki K; Ohkubo H; Ono Y (Dec 1999). "Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Res. Mol. Brain Res. (NETHERLANDS) 74 (1–2): 126–34. doi:10.1016/S0169-328X(99)00273-9. ISSN 0169-328X. PMID 10640683. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.