NEUROG3

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Neurogenin 3
Identifiers
Symbols NEUROG3 ; Atoh5; Math4B; NGN-3; bHLHa7; ngn3
External IDs OMIM604882 MGI893591 HomoloGene40692 GeneCards: NEUROG3 Gene
Orthologs
Species Human Mouse
Entrez 50674 11925
Ensembl ENSG00000122859 ENSMUSG00000044312
UniProt Q9Y4Z2 P70661
RefSeq (mRNA) NM_020999 NM_009719
RefSeq (protein) NP_066279 NP_033849
Location (UCSC) Chr 10:
71.33 – 71.33 Mb
Chr 10:
62.13 – 62.13 Mb
PubMed search [1] [2]

Neurogenin-3 is a protein that in humans is encoded by the NEUROG3 gene.[1]

Neurogenin-3 is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine.[2] It belongs to a family of basic helix-loop-helix (bHLH) transcription factors involved in the determination of neural precursor cells in the neuroectoderm.[3]

The pancreas and brain the major splicing isoform does not code for a protein.[4]

References[edit]

  1. ^ "Entrez Gene: neurogenin 3". 
  2. ^ Wang J, Cortina G, Wu SV, Tran R, Cho JH, Tsai MJ, Bailey TJ, Jamrich M, Ament ME, Treem WR, Hill ID, Vargas JH, Gershman G, Farmer DG, Reyen L, Martín MG (July 2006). "Mutant neurogenin-3 in congenital malabsorptive diarrhea". N. Engl. J. Med. 355 (3): 270–80. doi:10.1056/NEJMoa054288. PMID 16855267. 
  3. ^ Gradwohl G, Dierich A, LeMeur M, Guillemot F (February 2000). "neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas". Proc. Natl. Acad. Sci. U.S.A. 97 (4): 1607–11. doi:10.1073/pnas.97.4.1607. PMC 26482. PMID 10677506. 
  4. ^ Kanadia RN, Cepko CL (February 2010). "Alternative splicing produces high levels of noncoding isoforms of bHLH transcription factors during development". Genes Dev. 24 (3): 229–34. doi:10.1101/gad.1847110. PMC 2811824. PMID 20080942.  (Retracted, see "Retraction. Alternative splicing produces high levels of noncoding isoforms of bHLH transcription factors during development". Genes & development 25 (12): 1344. 2011. PMC 3127434. PMID 21685368. )

Further reading[edit]

  • Lejonklou MH, Edfeldt K, Johansson TA, Stålberg P, Skogseid B (April 2009). "Neurogenin 3 and neurogenic differentiation 1 are retained in the cytoplasm of multiple endocrine neoplasia type 1 islet and pancreatic endocrine tumor cells". Pancreas 38 (3): 259–66. doi:10.1097/MPA.0b013e3181930818. PMID 19307926. 
  • del Bosque-Plata L, Lin J, Horikawa Y, Schwarz PE, Cox NJ, Iwasaki N, Ogata M, Iwamoto Y, German MS, Bell GI (March 2001). "Mutations in the coding region of the neurogenin 3 gene (NEUROG3) are not a common cause of maturity-onset diabetes of the young in Japanese subjects". Diabetes 50 (3): 694–6. doi:10.2337/diabetes.50.3.694. PMID 11246894. 
  • Cauchi S, Proença C, Choquet H, Gaget S, De Graeve F, Marre M, Balkau B, Tichet J, Meyre D, Vaxillaire M, Froguel P (March 2008). "Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study". J. Mol. Med. 86 (3): 341–8. doi:10.1007/s00109-007-0295-x. PMID 18210030. 
  • Jensen JN, Hansen L, Ekstrøm CT, Pociot F, Nerup J, Hansen T, Pedersen O (January 2001). "Polymorphisms in the neurogenin 3 gene (NEUROG) and their relation to altered insulin secretion and diabetes in the Danish Caucasian population". Diabetologia 44 (1): 123–6. doi:10.1007/s001250051589. PMID 11206403. 
  • Cauchi S, Meyre D, Durand E, Proença C, Marre M, Hadjadj S, Choquet H, De Graeve F, Gaget S, Allegaert F, Delplanque J, Permutt MA, Wasson J, Blech I, Charpentier G, Balkau B, Vergnaud AC, Czernichow S, Patsch W, Chikri M, Glaser B, Sladek R, Froguel P (2008). "Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value". PLoS ONE 3 (5): e2031. doi:10.1371/journal.pone.0002031. PMC 2346547. PMID 18461161. 
  • Louet JF, Smith SB, Gautier JF, Molokhia M, Virally ML, Kevorkian JP, Guillausseau PJ, Vexiau P, Charpentier G, German MS, Vaisse C, Urbanek M, Mauvais-Jarvis F (September 2008). "Gender and neurogenin3 influence the pathogenesis of ketosis-prone diabetes". Diabetes Obes Metab 10 (10): 912–20. doi:10.1111/j.1463-1326.2007.00830.x. PMID 18093211. 
  • Yokoi N, Kanamori M, Horikawa Y, Takeda J, Sanke T, Furuta H, Nanjo K, Mori H, Kasuga M, Hara K, Kadowaki T, Tanizawa Y, Oka Y, Iwami Y, Ohgawara H, Yamada Y, Seino Y, Yano H, Cox NJ, Seino S (August 2006). "Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects". Diabetes 55 (8): 2379–86. doi:10.2337/db05-1203. PMID 16873704. 
  • Milord E, Gragnoli C (October 2006). "NEUROG3 variants and type 2 diabetes in Italians". Minerva Med. 97 (5): 373–8. PMID 17146417. 
  • Li J, Bergmann A, Reimann M, Schulze J, Bornstein SR, Schwarz PE (March 2008). "Genetic variation of Neurogenin 3 is slightly associated with hyperproinsulinaemia and progression toward type 2 diabetes". Exp. Clin. Endocrinol. Diabetes 116 (3): 178–83. doi:10.1055/s-2007-992156. PMID 18072012. 
  • Dror V, Nguyen V, Walia P, Kalynyak TB, Hill JA, Johnson JD (December 2007). "Notch signalling suppresses apoptosis in adult human and mouse pancreatic islet cells". Diabetologia 50 (12): 2504–15. doi:10.1007/s00125-007-0835-5. PMID 17922104. 
  • Heremans Y, Van De Casteele M, in't Veld P, Gradwohl G, Serup P, Madsen O, Pipeleers D, Heimberg H (October 2002). "Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3". J. Cell Biol. 159 (2): 303–12. doi:10.1083/jcb.200203074. PMC 2173047. PMID 12403815. 
  • Jackson AE, Cassell PG, North BV, Vijayaraghavan S, Gelding SV, Ramachandran A, Snehalatha C, Hitman GA (August 2004). "Polymorphic variations in the neurogenic differentiation-1, neurogenin-3, and hepatocyte nuclear factor-1alpha genes contribute to glucose intolerance in a South Indian population". Diabetes 53 (8): 2122–5. doi:10.2337/diabetes.53.8.2122. PMID 15277395. 
  • Drenos F, Talmud PJ, Casas JP, Smeeth L, Palmen J, Humphries SE, Hingorani AD (June 2009). "Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk". Hum. Mol. Genet. 18 (12): 2305–16. doi:10.1093/hmg/ddp159. PMC 2685759. PMID 19336475. 
  • Okada T, Tobe K, Hara K, Yasuda K, Kawaguchi Y, Ikegami H, Ito C, Kadowaki T (February 2001). "Variants of neurogenin 3 gene are not associated with Type II diabetes in Japanese subjects". Diabetologia 44 (2): 241–4. doi:10.1007/s001250051606. PMID 11270683. 
  • Sommer L, Ma Q, Anderson DJ (1996). "neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS". Mol. Cell. Neurosci. 8 (4): 221–41. doi:10.1006/mcne.1996.0060. PMID 9000438. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.