NFATC3

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Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NFATC3 ; NFAT4; NFATX
External IDs OMIM602698 MGI103296 HomoloGene27827 GeneCards: NFATC3 Gene
RNA expression pattern
PBB GE NFATC3 210555 s at tn.png
PBB GE NFATC3 207416 s at tn.png
PBB GE NFATC3 210556 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4775 18021
Ensembl ENSG00000072736 ENSMUSG00000031902
UniProt Q12968 B5B2U1
RefSeq (mRNA) NM_004555 NM_010901
RefSeq (protein) NP_004546 NP_035031
Location (UCSC) Chr 16:
68.12 – 68.26 Mb
Chr 8:
106.06 – 106.13 Mb
PubMed search [1] [2]

Nuclear factor of activated T-cells, cytoplasmic 3 is a protein that in humans is encoded by the NFATC3 gene.[1][2]

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Four transcript variants encoding distinct isoforms have been identified for this gene.[2]

See also[edit]

References[edit]

  1. ^ Hoey T, Sun YL, Williamson K, Xu X (Jun 1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity 2 (5): 461–72. doi:10.1016/1074-7613(95)90027-6. PMID 7749981. 
  2. ^ a b "Entrez Gene: NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.