NFKB2

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Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Protein NFKB2 PDB 1a3q.png
PDB rendering based on 1a3q.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NFKB2 ; CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p105; p52
External IDs OMIM164012 MGI1099800 HomoloGene1873 ChEMBL: 3003 GeneCards: NFKB2 Gene
RNA expression pattern
PBB GE NFKB2 207535 s at tn.png
PBB GE NFKB2 209636 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4791 18034
Ensembl ENSG00000077150 ENSMUSG00000025225
UniProt Q00653 Q9WTK5
RefSeq (mRNA) NM_001077494 NM_001177369
RefSeq (protein) NP_001070962 NP_001170840
Location (UCSC) Chr 10:
104.15 – 104.16 Mb
Chr 19:
46.3 – 46.31 Mb
PubMed search [1] [2]

Nuclear factor NF-kappa-B p100 subunit is a protein that in humans is encoded by the NFKB2 gene.[1]

NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-kappa-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-kappa-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth. For reviews, see Chen et al. (1999) and Baldwin (1996).[supplied by OMIM][2]

Interactions[edit]

NFKB2 has been shown to interact with NFKBIE,[3] BCL3,[4][5] MAP3K8,[6] BTRC,[7][8] RELA,[6][9] RELB,[4][6] NFKB1,[6] REL[6][9] and TSC22D3.[10]

CVID Link[edit]

Mutation of the NFKB2 gene has been linked to Common variable immunodeficiency (CVID) as the cause of the disease. Other genes might also be responsible. The frequency of NFKB2 mutation in CVID population is yet to be established.[11]

See also[edit]

References[edit]

  1. ^ Schmid RM, Perkins ND, Duckett CS, Andrews PC, Nabel GJ (Sep 1991). "Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65". Nature 352 (6337): 733–6. doi:10.1038/352733a0. PMID 1876189. 
  2. ^ "Entrez Gene: NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)". 
  3. ^ Li, Z; Nabel G J (Oct 1997). "A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription". Mol. Cell. Biol. (UNITED STATES) 17 (10): 6184–90. ISSN 0270-7306. PMC 232469. PMID 9315679. 
  4. ^ a b Thornburg, Natalie J; Pathmanathan Rajadurai, Raab-Traub Nancy (Dec 2003). "Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma". Cancer Res. (United States) 63 (23): 8293–301. ISSN 0008-5472. PMID 14678988. 
  5. ^ Bours, V; Franzoso G; Azarenko V; Park S; Kanno T; Brown K; Siebenlist U (Mar 1993). "The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers". Cell (UNITED STATES) 72 (5): 729–39. doi:10.1016/0092-8674(93)90401-B. ISSN 0092-8674. PMID 8453667. 
  6. ^ a b c d e Bouwmeester, Tewis; Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. (England) 6 (2): 97–105. doi:10.1038/ncb1086. ISSN 1465-7392. PMID 14743216. 
  7. ^ Fong, Abraham; Sun Shao-Cong (Jun 2002). "Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100". J. Biol. Chem. (United States) 277 (25): 22111–4. doi:10.1074/jbc.C200151200. ISSN 0021-9258. PMID 11994270. 
  8. ^ Vatsyayan, Jaya; Qing Guoliang; Xiao Gutian; Hu Jing (Sep 2008). "SUMO1 modification of NF-kappaB2/p100 is essential for stimuli-induced p100 phosphorylation and processing". EMBO Rep. (England) 9 (9): 885–90. doi:10.1038/embor.2008.122. PMC 2529344. PMID 18617892. 
  9. ^ a b Scheinman, R I; Beg A A; Baldwin A S (Oct 1993). "NF-kappa B p100 (Lyt-10) is a component of H2TF1 and can function as an I kappa B-like molecule". Mol. Cell. Biol. (UNITED STATES) 13 (10): 6089–101. ISSN 0270-7306. PMC 364669. PMID 8413211. 
  10. ^ Ayroldi, E; Migliorati G; Bruscoli S; Marchetti C; Zollo O; Cannarile L; D'Adamio F; Riccardi C (Aug 2001). "Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB". Blood (United States) 98 (3): 743–53. doi:10.1182/blood.V98.3.743. ISSN 0006-4971. PMID 11468175. 
  11. ^ Chen, Karin; Emily M. Coonrod, Attila Kumánovics, Zechariah F. Franks, Jacob D. Durtschi, Rebecca L. Margraf, Wilfred Wu, Nahla M. Heikal, Nancy H. Augustine, Perry G. Ridge, Harry R. Hill, Lynn B. Jorde, Andrew S. Weyrich, Guy A. Zimmerman, Adi V. Gundlapalli, John F. Bohnsack, Karl V. Voelkerding (17 October 2013). "Germline Mutations in NFKB2 Implicate the Noncanonical NF-κB Pathway in the Pathogenesis of Common Variable Immunodeficiency.". The American Journal of Human Genetics. doi:10.1016/j.ajhg.2013.09.009. Retrieved 18 October 2013. 

Further reading[edit]

  • Schreck R, Albermann K, Baeuerle PA (1993). "Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review).". Free Radic. Res. Commun. 17 (4): 221–37. doi:10.3109/10715769209079515. PMID 1473734. 
  • Baldwin AS (1996). "The NF-kappa B and I kappa B proteins: new discoveries and insights.". Annu. Rev. Immunol. 14 (1): 649–83. doi:10.1146/annurev.immunol.14.1.649. PMID 8717528. 
  • Chen F, Castranova V, Shi X, Demers LM (1999). "New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases.". Clin. Chem. 45 (1): 7–17. PMID 9895331. 
  • Bottex-Gauthier C, Pollet S, Favier A, Vidal DR (2002). "[The Rel/NF-kappa-B transcription factors: complex role in cell regulation]". Pathol. Biol. 50 (3): 204–11. doi:10.1016/s0369-8114(02)00289-4. PMID 11980335. 
  • Garg A, Aggarwal BB (2002). "Nuclear transcription factor-kappaB as a target for cancer drug development.". Leukemia 16 (6): 1053–68. doi:10.1038/sj.leu.2402482. PMID 12040437. 

External links[edit]