This game mode is the newest mode of NFL Street 2, the player must create a character and win all of the street games in Bay City. The player must play pick-up games to recruit talent for a team. The pick-up games are made up of randomly generated players. As the game progresses, the player will need to find better talent. If the player is successful they will face Xzibit and his team of NFL stars. When the player completes Own The City mode, the created player can be imported to Madden NFL 2006, another successful football title, or can be imported to the NFL Challenge mode. The created player may also be played as in any of the Street Events in which players are selected as individuals instead of as a team (Crush the Carrier, Jump Ball Battle, Open Field Showdown).
NFL Challenge is the official mode of the NFL Street series. The player must build up a team in 150 days to face the NFL Stars by completing challenges, such as scoring 250,000 style points on the Dallas Cowboys. Winning the challenges gives the player development points to spend on the players but also at the expense of days. When 5 days remain, a tournament opens up and the player's team must win the tournament to complete NFL Challenge (An alternative is to beat Team Xzibit in Own The City Mode). If the player advances into the final round, they face the NFL Legends, a team of NFL stars from the 1970s, 80s and 90s. If they win they unlock the team.
One of the new features in NFL Street 2 is the addition of the Gamebreaker 2. The player first has to acquire 100,000 style points to unlock a gamebreaker and then without using their gamebreaker, acquire the same amount of style points again. When called at the line of scrimmage, A cutscene occurs in which on defense, the defense stylishly gets the ball back while on offense, the offense stylishly gets over the line of scrimmage. After the cutscene, the player enters a "god mode" in which he has unlimited turbo and will break all of his tackles.
The game received positive reviews. IGN gave the PS2 edition an 8.9/10, praising the overall game but criticizing the sound, a common issue in EA Sports games. The PSP version received a 7.8/10 from IGN, criticizing the loading times and comparing the game to the St. Louis Rams.