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Nuclear transcription factor, X-box binding 1
Symbols NFX1 ; NFX2; TEG-42; Tex42
External IDs OMIM603255 MGI1921414 HomoloGene1875 GeneCards: NFX1 Gene
EC number 6.3.2.-
Species Human Mouse
Entrez 4799 74164
Ensembl ENSG00000086102 ENSMUSG00000028423
UniProt Q12986 B1AY10
RefSeq (mRNA) NM_002504 NM_001290448
RefSeq (protein) NP_002495 NP_001277377
Location (UCSC) Chr 9:
33.29 – 33.37 Mb
Chr 4:
40.97 – 41.03 Mb
PubMed search [1] [2]

Transcriptional repressor NF-X1 is a protein that in humans is encoded by the NFX1 gene.[1][1][2][2][3]

MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-γ. Three alternative splice variants, each of which encodes a different isoform, have been identified.[4]


  1. ^ a b Song Z, Krishna S, Thanos D, Strominger JL, Ono SJ (Dec 1994). "A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor". J Exp Med 180 (5): 1763–74. doi:10.1084/jem.180.5.1763. PMC 2191754. PMID 7964459. 
  2. ^ a b Hume CR, Lee JS (Jan 1990). "Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors". Hum Immunol 26 (4): 288–309. doi:10.1016/0198-8859(89)90007-4. PMID 2511169. 
  3. ^ Arlotta P, Miyazaki D, Copeland NG, Gilbert DJ, Jenkins NA, Ono SJ (June 2002). "Murine NFX.1: isolation and characterization of its messenger RNA, mapping of its chromosomal location and assessment of its developmental expression". Immunology 106 (2): 173–81. doi:10.1046/j.1365-2567.2002.01416.x. PMC 1782705. PMID 12047746. 
  4. ^ "Entrez Gene: NFX1 nuclear transcription factor, X-box binding 1". 

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