NFYC

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Nuclear transcription factor Y, gamma
Protein NFYC PDB 1n1j.png
PDB rendering based on 1n1j.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NFYC ; CBF-C; CBFC; H1TF2A; HAP5; HSM; NF-YC
External IDs OMIM605344 MGI107901 HomoloGene7440 GeneCards: NFYC Gene
RNA expression pattern
PBB GE NFYC 202215 s at tn.png
PBB GE NFYC 202216 x at tn.png
PBB GE NFYC 211251 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4802 18046
Ensembl ENSG00000066136 ENSMUSG00000032897
UniProt Q13952 P70353
RefSeq (mRNA) NM_001142587 NM_001048168
RefSeq (protein) NP_001136059 NP_001041633
Location (UCSC) Chr 1:
41.16 – 41.24 Mb
Chr 4:
120.76 – 120.83 Mb
PubMed search [1] [2]

Nuclear transcription factor Y subunit gamma is a protein that in humans is encoded by the NFYC gene.[1][2][3]

Function[edit]

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit C, forms a tight dimer with the B subunit (NFYB), a prerequisite for subunit A (NFYA) association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. Additional regulation, preliminarily supported by the EST database, may be represented by alternative splicing in this subunit.[3]

Two microRNAs; miR-30c and miR-30e are located within introns of the nfyc gene. These microRNAs are actively transcribed in human insulin-producing beta cells in the pancreatic islets that also show high expression of nfyc and CDH1 genes. The expression of these intronic microRNAs is essential for maintaining the differentiated phenotype of human islet beta cells. Inhibition of miR-30 family microRNAs induces epithelial-mesenchymal transition of human pancreatic islet cells.[4]

Interactions[edit]

NFYC has been shown to interact with Myc.[5]

References[edit]

  1. ^ Sinha S, Maity SN, Seldin MF, de Crombrugghe B (Feb 1997). "Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor". Genomics 37 (2): 260–3. doi:10.1006/geno.1996.0555. PMID 8921405. 
  2. ^ Bellorini M, Zemzoumi K, Farina A, Berthelsen J, Piaggio G, Mantovani R (Aug 1997). "Cloning and expression of human NF-YC". Gene 193 (1): 119–25. doi:10.1016/S0378-1119(97)00109-1. PMID 9249075. 
  3. ^ a b "Entrez Gene: NFYC nuclear transcription factor Y, gamma". 
  4. ^ Joglekar MV, Patil D, Joglekar VM, Rao GV, Reddy DN, Mitnala S, Shouche Y, Hardikar AA (September–October 2009). "The miR-30 family microRNAs confer epithelial phenotype to human pancreatic cells". Islets 1 (2): 137–147. doi:10.4161/isl.1.2.9578. PMID 21099261. 
  5. ^ Taira T, Sawai M, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H (August 1999). "Cell cycle-dependent switch of up-and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y". J. Biol. Chem. 274 (34): 24270–9. doi:10.1074/jbc.274.34.24270. PMID 10446203. 

Further reading[edit]

External links[edit]


This article incorporates text from the United States National Library of Medicine, which is in the public domain.