NG2 glia

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NG2 glia, or polydendrocytes, are a type of oligodendrocyte precursor cells found in the mammalian central nervous system,[1] which are distinct from astrocytes and oligodendrocytes.[2] They get their name from the expression of NG2 proteoglycan on their surface. NG2 glia are believed to be the precursors of oligodendrocytes, although recent evidence suggests that they may have other distinct functions.[1] NG2 glia are homogeneously present in the grey and white matter. In white matter, they are found along unmyelinated axons [3] as well as myelinated axons, engulfing nodes of Ranvier.[4]





  1. ^ a b Nishiyama, A.; Komitova, M.; Suzuki, R.; Zhu, X. (2009). "Polydendrocytes (NG2 cells): Multifunctional cells with lineage plasticity". Nature Reviews Neuroscience 10 (1): 9–22. doi:10.1038/nrn2495. PMID 19096367.  edit
  2. ^ Raff, MC; Miller, RH; Noble, M (1983). "A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium". Nature 303 (5916): 390–396. doi:10.1038/303390a0. PMID 6304520. 
  3. ^ Ziskin, J. L.; Nishiyama, A.; Rubio, M.; Fukaya, M.; Bergles, D. E. (2007). "Vesicular release of glutamate from unmyelinated axons in white matter". Nature Neuroscience 10 (3): 321–330. doi:10.1038/nn1854. PMC 2140234. PMID 17293857.  edit
  4. ^ Butt, A. M.; Duncan, A.; Hornby, M. F.; Kirvell, S. L.; Hunter, A.; Levine, J. M.; Berry, M. (1999). "Cells expressing the NG2 antigen contact nodes of Ranvier in adult CNS white matter". Glia 26 (1): 84–91. doi:10.1002/(SICI)1098-1136(199903)26:1<84::AID-GLIA9>3.0.CO;2-L. PMID 10088675.  edit