Helix-loop-helix protein 1 is a protein that in humans is encoded by the NHLH1gene.
The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM]
Manetopoulos C, Hansson A, Karlsson J et al. (2003). "The LIM-only protein LMO4 modulates the transcriptional activity of HEN1". Biochem. Biophys. Res. Commun.307 (4): 891–9. doi:10.1016/S0006-291X(03)01298-1. PMID12878195.
Lipkowitz S, Göbel V, Varterasian ML et al. (1992). "A comparative structural characterization of the human NSCL-1 and NSCL-2 genes. Two basic helix-loop-helix genes expressed in the developing nervous system". J. Biol. Chem.267 (29): 21065–71. PMID1328219.