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Symbols NINL ; NLP; dJ691N24.1
External IDs OMIM609580 MGI1925427 HomoloGene57024 GeneCards: NINL Gene
RNA expression pattern
PBB GE RP4-691N24.1 207705 s at tn.png
More reference expression data
Species Human Mouse
Entrez 22981 78177
Ensembl ENSG00000101004 ENSMUSG00000068115
UniProt Q9Y2I6 Q6ZQ12
RefSeq (mRNA) NM_025176 NM_207204
RefSeq (protein) NP_079452 NP_997087
Location (UCSC) Chr 20:
25.43 – 25.57 Mb
Chr 2:
150.93 – 151.04 Mb
PubMed search [1] [2]

Ninein-like protein is a protein that in humans is encoded by the NINL gene.[1][2] It is part of the centrosome.[3]

Model organisms[edit]

Model organisms have been used in the study of NINL function. A conditional knockout mouse line, called Ninltm1a(EUCOMM)Wtsi[8][9] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[10][11][12] Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[6][13] Twenty five tests were carried out on mutant mice, however no significant abnormalities were observed.[6]


  1. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032. 
  2. ^ "Entrez Gene: RP4-691N24.1 KIAA0980 protein". 
  3. ^ Casenghi, Martina (2003). Functional characterization of the novel centrosomal protein Nlp (ninein-like protein) (PDF) (Ph.D thesis). 
  4. ^ "Salmonella infection data for Ninl". Wellcome Trust Sanger Institute. 
  5. ^ "Citrobacter infection data for Ninl". Wellcome Trust Sanger Institute. 
  6. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. 
  7. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  8. ^ "International Knockout Mouse Consortium". 
  9. ^ "Mouse Genome Informatics". 
  10. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.  edit
  11. ^ Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  12. ^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  13. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353. 

Further reading[edit]