National Institute of Pharmaceutical Education and Research, Hyderabad
||This article includes a list of references, related reading or external links, but its sources remain unclear because it lacks inline citations. (June 2012)|
|National Institute of Pharmaceutical Education and Research (NIPER)|
|Location||IDPL, Hyderabad, Andhra Pradesh (India)|
NIPER Hyderabad is a premier institute offering pharmaceutical sciences education. The institute caters to the need of pharmaceutical R&D laboratories and industry around the country.It is a National level institute in Pharmaceutical Sciences with proclaimed objectives of becoming centre of excellence for advance science and research in pharmaceutical sciences. Previously, there was only one NIPER at Mohali. Later, the Govt. of India (Ministry of Chemicals & Fertilizers) has started 6 such institutes under the aegis of this Ministry. NIPER-Hyderabad is one among them. This institute offers a 2 year PG degree course; MS (Pharm.) in 4 disciplines ( Medicinal Chemistry, Pharmacology, Toxicology and Pharmaceutical Analysis & Pharmaceutics ) and is located at the former R&D Centre of IDPL, Balangar, Hyderabad. Presently, Indian Institute of Chemical Technology (IICT), Hyderabad a premier CSIR Research Laboratories, is the Mentor Institute for NIPER, Hyderabad.
This is being developed as a National Centre to cater to the needs of pharmaceutical academia and the industry. Very soon, it is likely to become the Centre of Excellence for Advance Studies and Research in Pharmaceutical Sciences. Hence, the Govt. has awarded the status of “Institute of National Importance” to it. This institute will play an important role in the Human Resource Development for the ever growing Indian Pharmaceutical industry, which has been in the forefront of India’s science based industries with wide ranging capabilities in this important field of drug manufacture.
The campus and Infrastructure
The institute has its campus in its own site of 150-acre (0.61 km2) area, in Balanagar – Hyderabad. The campus, with its greenery frontage and well laid our and spacious buildings, provides and environment which is very much conducive to a bright educational pursuit.
- The lecture halls are quite spacious, well ventilated and are comfortable with decent furniture and projection system and other requirements.
- The library has a large collection of books in the subjects of the institute and subscribes to many journals of the concerned subjects. It is equipped with modern gadgets for literature collection and on line access to the any articles are provided if requested.
- Adequately equipped laboratories are provided.
- The Institute has a spacious auditorium, fully equipped with modern systems, for the institute’s seminars, conferences, etc. The Institute has a hostel at a short distance from the campus, with transportation provided. Rooms are allotted on shared basis. Accommodation for female students is also provided. A mess is available for food, at reasonable cost. Extra curricular facilities like TV rooms, volley ball, shuttle, table tennis are available.
Library and Information Centre
The library at NIPER-Hyderabad is being developed in a manner that it can eventually gain the status of National Library and Information Centre on Pharmaceutical Sciences. A beginning has been made with the subscription of 6 International and 9 National journals. The library has Chemical Abstracts from 1963 to 1983 and Cumulative Indices up to eleventh bound volumes. A number of CD-ROM databases such as International Pharmaceutical Abstracts and Drug Information Full Text (1963-1998 Scifinder-Scholar online bibliographic database for Chemical Abstracts also available. The library is accessible to all the Pharmacy professionals from the country information to the academia, Researchers and the industry personnel. The library has obtained institutional membership of IICT-Library.
At present NIPER-Hyderabad belongs to 400 Books for three disciplines which are M.S. (Pharm) in Medicinal Chemistry, Pharmaceutical Analysis and Pharmacology & Toxicology. Library possesses 14750 Books belongs to Old IDPL R & D Centre, 1500 bound volumes of journals and Chemical Abstracts & Biological Abstracts.
Molecular Modelling Laboratory and Computer Centre
Computer centre at NIPER-Hyderabad serves the needs of faculty, staff and students in updating the literature and communication. It also facilitates the faculty and students with 75 higher end desktops which are connected in network. In addition to Windows 7, Vista operating systems, this centre has general software like MS Office 2010, Antivirus and other free software e.g. Guassview, ChemDraw, Chem BioOffice, GOLD and other molecular modelling software. For day to day computer practicals and literature retrieval from internet, 50 desktops are utilized. For molecular modelling / Drug discovery research activities, NIPER-Hyderabad procured license for a complete suite of Molecular Operating Environment (MOE) software, Chemical Computing Group, Canada. For high performance computing, two work stations are available and are used for free modelling software like AUTODOCK, NAMD etc. This centre is equipped with 2 Mbit/s internet Lease Line (1:1) connectivity with six servers set up in a rack which allows the users to have access to the email, internet etc. These servers were installed with windows Server 2003 and Linux (Red hat) operating system. Programming compilers including C, C++ and Java have also been installed. Establishment institutional email facility in progress. NIPER Hyderabad also has access to scientific database i.e. ACS SciFinder. Other computer related accessories including high speed and network laser printer (colour and black & white) and scanners are also available. Computer laboratory kept opened from 8.00 AM till 8.00 PM for students and staff.
The institute offers education and research facilities in area of three pharmaceutical disciplines
1. Medicinal Chemistry department is engaged in the following areas of research
- Identification and validation of novel target sites for various therapeutic areas: Design and synthesis of new chemical entities as anticancer, antileishmanial, broad-spectrum antimalarial, antituberculosis, antihypertensive, antiinflammatory, antidiabatic compounds and multi-drug resistance reversal agents
- Asymmetric Synthesis: Development of methodologies for catalytic asymmetric synthesis-dynamic kinetic resolution, asymmetric protonation/ deprotonation, asymmetric epoxidation, asymmetric aziridation and asymmetric alkylation. Synthesis of chiral drugs
- Combinatorial Chemistry: Development of novel linkers and analytical protocols; generation of molecular libraries
- Peptide Synthesis: Synthesis of unnatural amino acids and their incorporation in the peptides of biological importance by using solution- and solid- phase synthesis protocols. Receptor binding studies on the TRH peptides
- Eco-friendly Processes: Development of new methodologies under solvent free condition, surface mediated reactions, microwave/ ultrasound assisted enhancement of reaction rates
- Computer Aided Drug Design: Molecular modeling methods based on molecular mechanics, Quantum mechanics. Analog based design of - Kinase, Phosphatase, Protease, HMG-CoA reductase, selective COX-2, and selective PDE4 inhibitors. PPAR- g and Angiotensin receptor antagonist, Alzeimer dementia by 3D-QSAR, CoMFA, and docking methods
2. Pharmaceutical Analysis department is involved in the diversified activities,including active involvement in industrial research projects.The key areas of research are :
- Physico-chemical characterization of new chemical entities
- Forced degradation (stress testing) and stability kinetics studies
- Preformulation studies
- Validated analytical method development including stability-indicating assays
- Accelerated stability testing
- Impurity profiling of drug substances
- Preparation of degradation product standards
3. Department of pharmaceutics has all the facilities to carry out the research needed to develop new formulations or to omit defects in previous marketed formulations.The departmental research activities are concentrated in the following areas:
- Nanotechnology in the area or polymeric and lipidic particles
- Surface fictionalization of nanoparticles
- Novel nanotherapeutics like dendrimers for targeted brain drug delivery for brain tumors and neuro-degenerative diseases
- API Crystal designing
- Mechanistic approach for release of drug
- Solubility enhancement of low soluble drugs
- Pharmacokinetic profiling of drugs
- Intranasal drug delivery system
- Transdermal and topical drug delivery systems
4. Pharmacology and Toxicology d/span>epartment has the facilities to carry out pharmacological screening of NCEs. The department can enter into project collaborations in regulatory toxicological testing, viz., acute, sub-chronic and chronic toxicity testing. The departmental research activities are concentrated in the following areas:
- Opioid tolerance, supersensitivity and dependence mechanisms
- Role of different subtypes of angiotensin receptors in hypertension and diabetic vascular complications
- Understanding the mechanisms of diabetic complication and development of NIDDM & insulin resistance models in rodents; screening of synthetic and natural products for their antidiabetic activity
- Role of alpha adrenoceptors in benign prostatic hyperplasia
- Understanding the molecular mechanisms involved in ischaemic stroke
- Evaluation of novel neuroprotective approaches for the treatment of cerebral ischemia
- Development of animal models of cerebral ischemia
- Understanding the mechanisms of diabetic neuropathy
- Role of adenosine receptors subtypes in diabetic neuropathic pain
- Evaluation of various neuroprotective approaches in diabetic neuropathy
- Screening of NCEs for antileismanial activity.
- Development of rat model for Alzheimer's disease and screening of NCEs on learning and memory in rats
- Production of monoclonal antibodies against Plasmodium yoelii nigeriensis antigens with the objective of characterization of protective antigens
- Molecular mechanisms of protection, cytoadherence, immune evasion and red cell invasion in malaria
- Biotherapeutics and chemotherapeutics evaluation of potential antimalarial, antitubercular, antileishmanial and antiamoebic agents in vitro and in vivo
- Study of the opioids-induced bidirectional molecular signaling within the neuroimmune network with a view to develop new immunomodulators.
- Histone modifications as targets for drug discovery
- Molecular mechanism involved in toxicant and oxidative stress induced process of cell death
NIPER Hyderabad is offering following courses in 4 disciplines
Discipline Courses offered Number of seats in the current year Medicinal Chemistry M.S. (Pharm) 30 Pharmacology & Toxicolog M.S. (Pharm) 15 Pharmaceutical Analysis M.S. (Pharm) 14 Pharmaceutics M.S. (Pharm) 16 8 Regulatory toxicolgy, 8 Process chemistry. Currently there are 32 Ph.D. students doing their research work in NIPER-Hyderabad. NIPER-Hyderabad also started MBA Pharm. from the year 2012.