NKIRAS2

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NFKB inhibitor interacting Ras-like 2
Identifiers
Symbols NKIRAS2 ; KBRAS2; kappaB-Ras2
External IDs OMIM604497 HomoloGene9738 GeneCards: NKIRAS2 Gene
Orthologs
Species Human Mouse
Entrez 28511 71966
Ensembl ENSG00000168256 ENSMUSG00000017837
UniProt Q9NYR9 Q9CR56
RefSeq (mRNA) NM_001001349 NM_028024
RefSeq (protein) NP_001001349 NP_082300
Location (UCSC) Chr 17:
40.16 – 40.18 Mb
Chr 11:
100.62 – 100.63 Mb
PubMed search [1] [2]

NF-κB inhibitor interacting Ras-like 2 is a protein that in humans is encoded by the NKIRAS2 gene.[1]

Model organisms[edit]

Model organisms have been used in the study of NKIRAS2 function. A conditional knockout mouse line, called Nkiras2tm1a(EUCOMM)Wtsi[4][5] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[6][7][8]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[3][9] Twenty one tests were carried out, but no significant abnormalities were observed.[3]

References[edit]

  1. ^ "Entrez Gene: NFKB inhibitor interacting Ras-like 2". Retrieved 2011-08-30. 
  2. ^ "Salmonella infection data for Nkiras2". Wellcome Trust Sanger Institute. 
  3. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  4. ^ "International Knockout Mouse Consortium". 
  5. ^ "Mouse Genome Informatics". 
  6. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.  edit
  7. ^ Dolgin E (2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  8. ^ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  9. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353. 

Further reading[edit]

  • Tago K, Funakoshi-Tago M, Sakinawa M, et al. (2010). "KappaB-Ras is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA.". J. Biol. Chem. 285 (40): 30622–33. doi:10.1074/jbc.M110.117028. PMID 20639196. 
  • Fenwick C, Na SY, Voll RE, et al. (2000). "A subclass of Ras proteins that regulate the degradation of IkappaB.". Science 287 (5454): 869–73. doi:10.1126/science.287.5454.869. PMID 10657303. 
  • Dieguez-Gonzalez R, Akar S, Calaza M, et al. (2009). "Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis.". Ann. Rheum. Dis. 68 (4): 579–83. doi:10.1136/ard.2007.087304. PMID 18434448.