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NK3 homeobox 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NKX3-1 ; BAPX2; NKX3; NKX3.1; NKX3A
External IDs OMIM602041 MGI97352 HomoloGene4494 GeneCards: NKX3-1 Gene
RNA expression pattern
PBB GE NKX3-1 209706 at tn.png
PBB GE NKX3-1 211497 x at tn.png
PBB GE NKX3-1 211498 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4824 18095
Ensembl ENSG00000167034 ENSMUSG00000022061
UniProt Q99801 P97436
RefSeq (mRNA) NM_001256339 NM_010921
RefSeq (protein) NP_001243268 NP_035051
Location (UCSC) Chr 8:
23.54 – 23.54 Mb
Chr 14:
69.19 – 69.19 Mb
PubMed search [1] [2]

Homeobox protein Nkx-3.1 is a protein that in humans is encoded by the NKX3-1 gene.[1]

The homeodomain-containing transcription factor NKX3A is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3A protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.[supplied by OMIM][2]


NKX3-1 has been shown to interact with SPDEF.[3]

The stability of NKX3-1 protein has been shown to be regulated by phosphorylation.[4]


  1. ^ He WW, Sciavolino PJ, Wing J, Augustus M, Hudson P, Meissner PS, Curtis RT, Shell BK, Bostwick DG, Tindall DJ, Gelmann EP, Abate-Shen C, Carter KC (September 1997). "A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer". Genomics 43 (1): 69–77. doi:10.1006/geno.1997.4715. PMID 9226374. 
  2. ^ "Entrez Gene: NKX3-1 NK3 transcription factor related, locus 1 (Drosophila)". 
  3. ^ Chen H, Nandi AK, Li X, Bieberich CJ (January 2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Research 62 (2): 338–40. PMID 11809674. 
  4. ^ Padmanabhan A, Gosc EB, Bieberich CJ (May 2013). "Stabilization of the prostate-specific tumor suppressor NKX3.1 by the oncogenic protein kinase Pim-1 in prostate cancer cells". Journal of Cellular Biochemistry 114 (5): 1050–7. doi:10.1002/jcb.24444. PMID 23129228. 

Further reading[edit]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.