Homeobox protein Nkx-3.1 is a protein that in humans is encoded by the NKX3-1gene.
The homeodomain-containing transcription factor NKX3A is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3A protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.[supplied by OMIM]
^Chen, Hui; Nandi Asit K; Li Xiang; Bieberich Charles J (January 2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Res. (United States) 62 (2): 338–40. ISSN0008-5472. PMID11809674.
Voeller HJ, Augustus M, Madike V, et al. (1997). "Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers.". Cancer Res.57 (20): 4455–9. PMID9377551.
Choi CY, Kim YH, Kwon HJ, Kim Y (1999). "The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription.". J. Biol. Chem.274 (47): 33194–7. doi:10.1074/jbc.274.47.33194. PMID10559189.
Carson JA, Fillmore RA, Schwartz RJ, Zimmer WE (2001). "The smooth muscle gamma-actin gene promoter is a molecular target for the mouse bagpipe homologue, mNkx3-1, and serum response factor.". J. Biol. Chem.275 (50): 39061–72. doi:10.1074/jbc.M006532200. PMID10993896.
Bowen C, Bubendorf L, Voeller HJ, et al. (2000). "Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression.". Cancer Res.60 (21): 6111–5. PMID11085535.
Korkmaz KS, Korkmaz CG, Ragnhildstveit E, et al. (2001). "Full-length cDNA sequence and genomic organization of human NKX3A - alternative forms and regulation by both androgens and estrogens.". Gene260 (1–2): 25–36. doi:10.1016/S0378-1119(00)00453-4. PMID11137288.
Chen H, Nandi AK, Li X, Bieberich CJ (2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Res.62 (2): 338–40. PMID11809674.
Filmore RA, Dean DA, Zimmer WE (2003). "The smooth muscle gamma-actin gene is androgen responsive in prostate epithelia". Gene Expr.10 (5–6): 201–11. PMID12450213.
Asatiani E, Huang WX, Wang A, et al. (2005). "Deletion, methylation, and expression of the NKX3.1 suppressor gene in primary human prostate cancer". Cancer Res.65 (4): 1164–73. doi:10.1158/0008-5472.CAN-04-2688. PMID15734999.