NLGN4X

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Neuroligin 4, X-linked
Protein NLGN4X PDB 2WQZ.png
Rendering based on PDB 2WQZ.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NLGN4X ; ASPGX2; AUTSX2; HLNX; HNL4X; HNLX; NLGN; NLGN4
External IDs OMIM300427 HomoloGene124472 GeneCards: NLGN4X Gene
RNA expression pattern
PBB GE NLGN4X 221933 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 57502 n/a
Ensembl ENSG00000146938 n/a
UniProt Q8N0W4 n/a
RefSeq (mRNA) NM_020742 n/a
RefSeq (protein) NP_065793 n/a
Location (UCSC) Chr X:
5.76 – 6.15 Mb
n/a
PubMed search [1] n/a

Neuroligin-4, X-linked is a protein that in humans is encoded by the NLGN4X gene.[1][2]

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligins may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs, large (Drosophila) homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Two transcript variants encoding the same protein have been identified for this gene.[2]

References[edit]

  1. ^ Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Jan 2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462. 
  2. ^ a b "Entrez Gene: NLGN4X neuroligin 4, X-linked". 

Further reading[edit]