NLRC4

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NLR family, CARD domain containing 4
Identifiers
Symbols NLRC4 ; CARD12; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; IPAF
External IDs OMIM606831 MGI3036243 HomoloGene10924 GeneCards: NLRC4 Gene
Orthologs
Species Human Mouse
Entrez 58484 268973
Ensembl ENSG00000091106 ENSMUSG00000039193
UniProt Q9NPP4 Q3UP24
RefSeq (mRNA) NM_001199138 NM_001033367
RefSeq (protein) NP_001186067 NP_001028539
Location (UCSC) Chr 2:
32.45 – 32.49 Mb
Chr 17:
74.43 – 74.46 Mb
PubMed search [1] [2]

NLR family CARD domain-containing protein 4 is a protein that in humans is encoded by the NLRC4 gene.[1][2]

In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1 (CARD4; MIM 605980), and NOD2 (CARD15; MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.[supplied by OMIM][2]

Interactions[edit]

NLRC4 has been shown to interact with caspase 1[3][4] and NOD2.[3][4]

References[edit]

  1. ^ Geddes BJ, Wang L, Huang WJ, Lavellee M, Manji GA, Brown M, Jurman M, Cao J, Morgenstern J, Merriam S, Glucksmann MA, DiStefano PS, Bertin J (May 2001). "Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis". Biochem Biophys Res Commun 284 (1): 77–82. doi:10.1006/bbrc.2001.4928. PMID 11374873. 
  2. ^ a b "Entrez Gene: NLRC4 NLR family, CARD domain containing 4". 
  3. ^ a b Damiano, Jason S; Oliveira Vasco; Welsh Kate; Reed John C (Jul 2004). "Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses". Biochem. J. (England) 381 (Pt 1): 213–9. doi:10.1042/BJ20031506. PMC 1133779. PMID 15107016. 
  4. ^ a b Damiano, J S; Stehlik C; Pio F; Godzik A; Reed J C (Jul 2001). "CLAN, a novel human CED-4-like gene". Genomics (United States) 75 (1-3): 77–83. doi:10.1006/geno.2001.6579. ISSN 0888-7543. PMID 11472070. 

Further reading[edit]