NLRC5, short for NOD-like receptor family CARD domain containing 5, is an intracellular protein that plays a role in the immune system. NLRC5 is a pattern recognition receptor implicated in innate immunity to viruses potentially by regulating interferon activity. [1 ] [2 ] [3 ]
Recently, NLRC5 has been suggested to play a positive role in the regulation of
Major Histocompatibility Class I (MHCI) molecule expression. This aspect of NLRC5 function was further investigated with the help of [4 ] Nlrc5- deficient mice, which showed reduced MHCI expression in lymphocytes (particularly T, NK and NKT lymphocytes). In lymphocytes, NLRC5 localizes to the [5 ] nucleus and drives MHCI gene expression by occupying H-2D and H-2K gene promoters. [5 ]
In humans, the NLRC5
protein is encoded by the NLRC5 gene. It has also been called NOD27, NOD4, and CLR16.1. [6 ]
References [ edit ]
^ Neerincx A, Lautz K, Menning M, et al. (June 2010). "A Role for the Human Nucleotide-binding Domain, Leucine-rich Repeat-containing Family Member NLRC5 in Antiviral Responses". J Biol Chem 285 (34): 26223–32. doi: 10.1074/jbc.M110.109736. PMC 2924034. PMID 20538593.
^ Cui J, Zhu L, Xia X, et al. (April 2010). "NLRC5 negatively regulates the NF-κB and type I interferon signaling pathways and antiviral immunity". Cell 141 (3): 483–96. doi: 10.1016/j.cell.2010.03.040. PMC 3150216. PMID 20434986.
^ Kuenzel S, Till A, Winkler M, et al. (February 2010). "The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses". J. Immunol. 184 (4): 1990–2000. doi: 10.4049/jimmunol.0900557. PMID 20061403.
^ Meissner TB; Li A; Biswas A; Lee K; Liu Y; Bayir E; Iliopoulos D; van den Elsen PJ and Kobayashi KS (August 2010). "NLR family member NLRC5 is a transcriptional regulator of MHC class I genes". Proc. Natl. Acad. Sci. 107 (31): 13794–13799. doi: 10.1073/pnas.1008684107. PMID 22310711 . Retrieved 23 March 2012.
^ a b Staehli F; Ludigs K; Heinz LX; Seguín-Estévez Q; Ferrero I; Braun M; Schroder K; Rebsamen M; Tardivel A; Mattmann C; MacDonald HR; Romero P; Reith W; Guarda G and Tschopp J (April 2012). "NLRC5 Deficiency Selectively Impairs MHC Class I-Dependent Lymphocyte Killing by Cytotoxic T Cells". J Immunol 188 (8). doi: 10.4049/jimmunol.1102671. PMID 22412192 . Retrieved 23 March 2012.
^ Dowds TA, Masumoto J, Chen FF, Ogura Y, Inohara N, Núñez G (March 2003). "Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product". Biochem. Biophys. Res. Commun. 302 (3): 575–80. doi: 10.1016/S0006-291X(03)00221-3. PMID 12615073.