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NLR family, pyrin domain containing 12
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NLRP12 ; CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2
External IDs OMIM609648 HomoloGene16972 IUPHAR: 1779 GeneCards: NLRP12 Gene
Species Human Mouse
Entrez 91662 378425
Ensembl ENSG00000142405 ENSMUSG00000078817
UniProt P59046 E9Q5R7
RefSeq (mRNA) NM_001277126 NM_001033431
RefSeq (protein) NP_001264055 NP_001028603
Location (UCSC) Chr 19:
54.3 – 54.33 Mb
Chr 7:
3.22 – 3.25 Mb
PubMed search [1] [2]

NACHT, LRR and PYD domains-containing protein 12 is a protein that in humans is encoded by the NLRP12 gene.[1][2][3]

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP12, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).[supplied by OMIM][3]


  1. ^ Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. 
  2. ^ Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J (Aug 2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J Biol Chem 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269. 
  3. ^ a b "Entrez Gene: NLRP12 NLR family, pyrin domain containing 12". 

Further reading[edit]