From Wikipedia, the free encyclopedia
Jump to: navigation, search
NLR family, pyrin domain containing 14
Symbols NLRP14 ; CLR11.2; GC-LRR; NALP14; NOD5; PAN8
External IDs OMIM609665 MGI1924108 HomoloGene18531 GeneCards: NLRP14 Gene
Species Human Mouse
Entrez 338323 76858
Ensembl ENSG00000158077 ENSMUSG00000016626
UniProt Q86W24 Q6B966
RefSeq (mRNA) NM_176822 NM_001002894
RefSeq (protein) NP_789792 NP_001002894
Location (UCSC) Chr 11:
7.04 – 7.09 Mb
Chr 7:
107.17 – 107.2 Mb
PubMed search [1] [2]

NLRP14, short for NOD-like receptor family pyrin domain containing 14, is an intracellular protein of mammals associated with a role in spermatogenesis. It is also known as NALP14, NOD5, GC-LRR, Nalp-iota, PAN8, and CLR11.2, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors.[1] NLRP14 is found exclusively in the testes where it is expressed within spermatogonia, spermatocytes and spermatids.[2]


  1. ^ Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. 
  2. ^ Westerveld GH, Korver CM, van Pelt AM, et al. (December 2006). "Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure". Hum. Reprod. 21 (12): 3178–84. doi:10.1093/humrep/del293. PMID 16931801. 

Further reading[edit]