From Wikipedia, the free encyclopedia
Jump to: navigation, search
NLR family, pyrin domain containing 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NLRP2 ; CLR19.9; NALP2; NBS1; PAN1; PYPAF2
External IDs OMIM609364 MGI3041206 HomoloGene56789 IUPHAR: 1769 GeneCards: NLRP2 Gene
Species Human Mouse
Entrez 55655 232827
Ensembl ENSG00000022556 ENSMUSG00000035177
UniProt Q9NX02 Q4PLS0
RefSeq (mRNA) NM_001174081 NM_177690
RefSeq (protein) NP_001167552 NP_808358
Location (UCSC) Chr 19:
55.46 – 55.51 Mb
Chr 7:
5.3 – 5.35 Mb
PubMed search [1] [2]

NACHT, LRR and PYD domains-containing protein 2 is a protein that in humans is encoded by the NLRP2 gene.[1][2][3]

NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003).[supplied by OMIM][3]


  1. ^ Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. 
  2. ^ Bertin J, DiStefano PS (Mar 2001). "The PYRIN domain: a novel motif found in apoptosis and inflammation proteins". Cell Death Differ 7 (12): 1273–4. doi:10.1038/sj.cdd.4400774. PMID 11270363. 
  3. ^ a b "Entrez Gene: NLRP2 NLR family, pyrin domain containing 2". 

Further reading[edit]