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NLR family, pyrin domain containing 4
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NLRP4 ; CLR19.5; CT58; NALP4; PAN2; PYPAF4; RNH2
External IDs OMIM609645 MGI3056600 HomoloGene75315 IUPHAR: 1771 GeneCards: NLRP4 Gene
Species Human Mouse
Entrez 147945 83564
Ensembl ENSG00000160505 ENSMUSG00000034690
UniProt Q96MN2 Q3TKR3
RefSeq (mRNA) NM_134444 NM_031389
RefSeq (protein) NP_604393 NP_113566
Location (UCSC) Chr 19:
56.35 – 56.39 Mb
Chr 7:
6.05 – 6.11 Mb
PubMed search [1] [2]

NACHT, LRR and PYD domains-containing protein 4 is a protein that in humans is encoded by the NLRP4 gene.[1][2][3]

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).[supplied by OMIM][3]


  1. ^ Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. 
  2. ^ Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J (Aug 2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J Biol Chem 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269. 
  3. ^ a b "Entrez Gene: NLRP4 NLR family, pyrin domain containing 4". 

Further reading[edit]