From Wikipedia, the free encyclopedia
Jump to: navigation, search
NLR family, pyrin domain containing 6
External IDs OMIM609650 MGI2141990 HomoloGene15881 GeneCards: NLRP6 Gene
Species Human Mouse
Entrez 171389 101613
Ensembl ENSG00000174885 ENSMUSG00000038745
UniProt P59044 Q91WS2
RefSeq (mRNA) NM_001276700 NM_001081389
RefSeq (protein) NP_001263629 NP_001074858
Location (UCSC) Chr 11:
0.28 – 0.29 Mb
Chr 7:
140.92 – 140.93 Mb
PubMed search [1] [2]

NLRP6, short for NOD-like receptor family pyrin domain containing 6, is an intracellular protein that plays a role in the immune system. It is also known as NALP6, PYPAF5, PAN3, and CLR11.4, and is one of 14 pyrin domain containing members of the NOD-like receptor family of pattern recognition receptors. As with several other NOD-like receptors, NLRP6's role in immunity is related to its ability to regulate caspase-1 and NF-κB activity.[1]


  1. ^ Grenier JM, Wang L, Manji GA, et al. (October 2002). "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1". FEBS Lett. 530 (1–3): 73–8. doi:10.1016/S0014-5793(02)03416-6. PMID 12387869. 

Further reading[edit]

  • Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496. 
  • Albrecht M, Domingues FS, Schreiber S, Lengauer T (2003). "Identification of mammalian orthologs associates PYPAF5 with distinct functional roles". FEBS Lett. 538 (1–3): 173–7. doi:10.1016/S0014-5793(03)00161-3. PMID 12633874. 
  • Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. 
  • Wang L, Manji GA, Grenier JM, et al. (2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J. Biol. Chem. 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269.