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NLR family, pyrin domain containing 7
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NLRP7 ; CLR19.4; HYDM; NALP7; NOD12; PAN7; PYPAF3
External IDs OMIM609661 HomoloGene51401 GeneCards: NLRP7 Gene
Species Human Mouse
Entrez 199713 n/a
Ensembl ENSG00000167634 n/a
UniProt Q8WX94 n/a
RefSeq (mRNA) NM_001127255 n/a
RefSeq (protein) NP_001120727 n/a
Location (UCSC) Chr 19:
54.92 – 54.97 Mb
PubMed search [1] n/a

NACHT, LRR and PYD domains-containing protein 7 is a protein that in humans is encoded by the NLRP7 gene.[1][2][3]


NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP7, have an N-terminal pyrin (MEFV) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1) via their involvement in multiprotein complexes called inflammasomes.[3]


  1. ^ Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. 
  2. ^ Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J (Aug 2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J Biol Chem 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269. 
  3. ^ a b "Entrez Gene: NLRP7 NLR family, pyrin domain containing 7". 

Further reading[edit]