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NLR family, pyrin domain containing 8
Symbols NLRP8 ; CLR19.2; NALP8; NOD16; PAN4
External IDs OMIM609659 HomoloGene82360 IUPHAR: 1775 GeneCards: NLRP8 Gene
Species Human Mouse
Entrez 126205 n/a
Ensembl ENSG00000179709 n/a
UniProt Q86W28 n/a
RefSeq (mRNA) NM_176811 n/a
RefSeq (protein) NP_789781 n/a
Location (UCSC) Chr 19:
56.46 – 56.5 Mb
PubMed search [1] n/a

NLRP8, short for NOD-like receptor family pyrin domain containing 8, is an intracellular protein that is expressed in the ovaries, testes, and preimplantation embryos of mammals.[1][2] It is also known as NALP8, NOD16, PAN4, and CLR19.2, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors.


  1. ^ Ponsuksili S, Brunner RM, Goldammer T et al. (March 2006). "Bovine NALP5, NALP8, and NALP9 genes: assignment to a QTL region and the expression in adult tissues, oocytes, and preimplantation embryos". Biol. Reprod. 74 (3): 577–84. doi:10.1095/biolreprod.105.045096. PMID 16339045. 
  2. ^ Tian X, Pascal G, Monget P (2009). "Evolution and functional divergence of NLRP genes in mammalian reproductive systems". BMC Evol. Biol. 9: 202. doi:10.1186/1471-2148-9-202. PMC 2735741. PMID 19682372. 

Further reading[edit]

  • Enjuanes A, Benavente Y, Bosch F et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.". Cancer Res. 68 (24): 10178–86. doi:10.1158/0008-5472.CAN-08-2221. PMID 19074885. 
  • Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis.". Nat. Rev. Immunol. 3 (5): 371–82. doi:10.1038/nri1086. PMID 12766759. 
  • Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation.". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287.