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NLR family member X1
3un9 ctermhex.png
C-terminal RNA binding domain of NLXR1 hexamer. PDB 3un9[1]
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NLRX1 ; CLR11.3; DLNB26; NOD26; NOD5; NOD9
External IDs OMIM611947 MGI2429611 HomoloGene11623 IUPHAR: 1766 GeneCards: NLRX1 Gene
Species Human Mouse
Entrez 79671 270151
Ensembl ENSG00000160703 ENSMUSG00000032109
UniProt Q86UT6 Q3TL44
RefSeq (mRNA) NM_024618 NM_001163742
RefSeq (protein) NP_078894 NP_001157214
Location (UCSC) Chr 11:
119.04 – 119.05 Mb
Chr 9:
44.25 – 44.27 Mb
PubMed search [1] [2]

NLRX1 or NLR family member X1, short for nucleotide-binding oligomerization domain, leucine rich repeat containing X1, is an intracellular protein that plays a role in the immune system. It is also known as NOD-like receptor X1, NLR family, X1, NOD5, NOD9, and CLR11.3, and is a member of the NOD-like receptor family of pattern recognition receptors. NLRX1 was proposed to affect innate immunity to viruses by interfering with the mitochondrial antiviral signaling protein (MAVS)/retinoic-acid-inducible gene I (RIG-I) mitochondrial antiviral pathway.,[2] although this was recently questioned.[3][4]

NLRX1 has a unique protein structure composed of 3 protein domains: an N-terminal effector domain containing a mitochondrion localization signal; a central NACHT domain; a C-terminal leucine-rich repeat (LRR) domain.[5]

In humans, the NLRX1 protein is encoded by the NLRX1 gene.[6][7]


  1. ^ Hong, M.; Yoon, S. I.; Wilson, I. A. (2012). "Structure and Functional Characterization of the RNA-Binding Element of the NLRX1 Innate Immune Modulator". Immunity 36 (3): 337–347. doi:10.1016/j.immuni.2011.12.018. PMID 22386589.  edit
  2. ^ O'Neill LA (April 2008). "Innate immunity: squelching anti-viral signalling with NLRX1". Curr. Biol. 18 (7): R302–4. doi:10.1016/j.cub.2008.02.021. PMID 18397740. 
  3. ^ Rebsamen M, Vazquez J, Tardivel A, Guarda G, Curran J, Tschopp J (August 2011). "NLRX1/NOD5 deficiency does not affect MAVS signalling". Cell Death Differ. 18 (8): 1387. doi:10.1038/cdd.2011.64. PMC 3172102. PMID 21617692. 
  4. ^ Soares F, Tattoli I, Wortzman ME, Arnoult D, Philpott DJ, Girardin SE (2013). "NLRX1 does not inhibit MAVS-dependent antiviral signalling". Innate Immun 19 (4): 438–48. doi:10.1177/1753425912467383. PMID 23212541. 
  5. ^ Meylan E, Tschopp J (March 2008). "NLRX1: friend or foe?". EMBO Rep. 9 (3): 243–5. doi:10.1038/embor.2008.23. PMC 2267384. PMID 18311173. 
  6. ^ "Entrez Gene: NLR family member X1". 
  7. ^ Inohara N, Nuñez G (May 2003). "NODs: intracellular proteins involved in inflammation and apoptosis". Nat. Rev. Immunol. 3 (5): 371–82. doi:10.1038/nri1086. PMID 12766759. 

Further reading[edit]