NNC 63-0532

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NNC 63-0532
NNC630532.png
Systematic (IUPAC) name
methyl [8-(1-naphthylmethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl)acetate
Clinical data
Legal status
?
Identifiers
CAS number 250685-44-0 YesY
ATC code ?
PubChem CID 9803475
Synonyms NNC 63-0532
Chemical data
Formula C27H29N3O3 
Mol. mass 443.536 g/mol
 YesY (what is this?)  (verify)

NNC 63-0532 is an nociceptoid drug used in scientific research. It acts as a potent and selective agonist for the nociceptin receptor, also known as the ORL-1 (opiate receptor like-1) receptor.[1][2] The function of this receptor is still poorly understood, but it is thought to have roles in many disorders such as pain, drug addiction, development of tolerance to opioid drugs, and psychological disorders such as anxiety and depression. Research into the function of this receptor is an important focus of current pharmaceutical development and selective agents such as NNC 63-0532 are essential for this work.[3]

References[edit]

  1. ^ Thomsen C, Hohlweg R. (8-Naphthalen-1-ylmethyl-4-oxo-1-phenyl-1,3,8-triaza-spiro[4. 5]dec-3-yl)-acetic acid methyl ester (NNC 63-0532) is a novel potent nociceptin receptor agonist. British Journal of Pharmacology. 2000 Nov;131(5):903-8. PMID 11053209
  2. ^ Guerrini R, Carra' G, Calo' G, Trapella C, Marzola E, Rizzi D, Regoli D, Salvadori S. Nonpeptide/peptide chimeric ligands for the nociceptin/orphanin FQ receptor: design, synthesis and in vitro pharmacological activity. Journal of Peptide Research. 2004 Jun;63(6):477-84. PMID 15175020
  3. ^ Chiou LC, Liao YY, Fan PC, Kuo PH, Wang CH, Riemer C, Prinssen EP. Nociceptin/orphanin FQ peptide receptors: pharmacology and clinical implications. Current Drug Targets. 2007 Jan;8(1):117-35. PMID 17266536