NONMEM

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NONMEM is a software package developed by Stuart L. Beal and Lewis B. Sheiner in the late 1970s at UCSF for population pharmacokinetic modeling.[1][2][3][4] Its name is an acronym for non-linear mixed effects modeling and has become the "gold standard"[citation needed], both in the pharmaceutical industry and academia.

References[edit]

  1. ^ Sheiner, Lewis B.; B. Rosenberg, V.V. Marathe (1977). "Evaluation of Methods for Estimating Population Pharmacokinetic Parameters I. Michaelis-Menten Model: Routine Clinical Pharmacokinetic Data". Journal of Pharmacokinetics and Biopharmaceutics 5 (5): 445–79. doi:10.1007/BF01061728. PMID 925881. 
  2. ^ Sheiner, Lewis B.; Stuart L. Beal (1980). "Evaluation of Methods for Estimating Population Pharmacokinetic Parameters I. Michaelis-Menten Model: Routine Clinical Pharmacokinetic Data". Journal of Pharmacokinetics and Biopharmaceutics 8 (6): 553–71. doi:10.1007/BF01060053. 
  3. ^ Sheiner, Lewis B.; Stuart L. Beal (1981). "Evaluation of Methods for Estimating Population Pharmacokinetic Parameters II. Biexponential Model and Experimental Pharmacokinetic Data". Journal of Pharmacokinetics and Biopharmaceutics 9 (5): 635–51. doi:10.1007/BF01061030. 
  4. ^ Sheiner, Lewis B.; Stuart L. Beal (1983). "Evaluation of Methods for Estimating Population Pharmacokinetic Parameters III. Monoexponential Model: Routine Clinical Pharmacokinetic Data". Journal of Pharmacokinetics and Biopharmaceutics 11 (3): 303–19. doi:10.1007/BF01061870. 

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