NOS1

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Nitric oxide synthase 1 (neuronal)
PDB 1b8q EBI.jpg
Rendering of 1b8q
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NOS1 ; IHPS1; N-NOS; NC-NOS; NOS; bNOS; nNOS
External IDs OMIM163731 MGI97360 HomoloGene37327 ChEMBL: 3568 GeneCards: NOS1 Gene
EC number 1.14.13.39
RNA expression pattern
PBB GE NOS1 207309 at tn.png
PBB GE NOS1 207310 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4842 18125
Ensembl ENSG00000089250 ENSMUSG00000029361
UniProt P29475 Q9Z0J4
RefSeq (mRNA) NM_000620 NM_008712
RefSeq (protein) NP_000611 NP_032738
Location (UCSC) Chr 12:
117.65 – 117.89 Mb
Chr 5:
117.78 – 117.96 Mb
PubMed search [1] [2]

Nitric oxide synthase 1 (neuronal), also known as NOS1, is an enzyme that in humans is encoded by the NOS1 gene.[1][2]

Function[edit]

Nitric oxide (NO) is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter and may be involved in long term potentiation. It is implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. NO is also responsible for endothelium-derived relaxing factor activity regulating blood pressure. In macrophages, NO mediates tumoricidal and bactericidal actions, as indicated by the fact that inhibitors of NO synthase (NOS) block these effects. Neuronal NOS and macrophage NOS are distinct isoforms.[3] Both the neuronal and the macrophage forms are unusual among oxidative enzymes in requiring several electron donors: FAD, flavin mononucleotide (FMN), NADPH, and tetrahydrobiopterin.[4]

Clinical significance[edit]

It has been implicated in asthma,[5][6] schizophrenia[7][8] and restless leg syndrome.[9] It has also been investigated with respect to bipolar disorder [10] and air pollution exposure.[11]

Interactions[edit]

NOS1 has been shown to interact with DLG4[12][13] and NOS1AP.[12]

See also[edit]

References[edit]

  1. ^ Kishimoto J, Spurr N, Liao M, Lizhi L, Emson P, Xu W (November 1992). "Localization of brain nitric oxide synthase (NOS) to human chromosome 12". Genomics 14 (3): 802–4. doi:10.1016/S0888-7543(05)80192-2. PMID 1385308. 
  2. ^ Geller DA, Lowenstein CJ, Shapiro RA, Nussler AK, Di Silvio M, Wang SC, Nakayama DK, Simmons RL, Snyder SH, Billiar TR (April 1993). "Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes". Proc. Natl. Acad. Sci. U.S.A. 90 (8): 3491–5. doi:10.1073/pnas.90.8.3491. PMC 46326. PMID 7682706. 
  3. ^ Lowenstein CJ, Glatt CS, Bredt DS, Snyder SH (August 1992). "Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme". Proc. Natl. Acad. Sci. U.S.A. 89 (15): 6711–5. doi:10.1073/pnas.89.15.6711. PMC 49573. PMID 1379716. 
  4. ^ "Entrez Gene: NOS1 Nitric oxide synthase 1 (neuronal)". 
  5. ^ Grasemann H, Yandava CN, Drazen JM (December 1999). "Neuronal NO synthase (NOS1) is a major candidate gene for asthma". Clin. Exp. Allergy. 29. Suppl 4: 39–41. PMID 10641565. 
  6. ^ Leung TF, Liu EK, Tang NL, Ko FW, Li CY, Lam CW, Wong GW (October 2005). "Nitric oxide synthase polymorphisms and asthma phenotypes in Chinese children". Clin. Exp. Allergy 35 (10): 1288–94. doi:10.1111/j.1365-2222.2005.02342.x. PMID 16238787. 
  7. ^ Shinkai T, Ohmori O, Hori H, Nakamura J (2002). "Allelic association of the neuronal nitric oxide synthase (NOS1) gene with schizophrenia". Mol. Psychiatry 7 (6): 560–3. doi:10.1038/sj.mp.4001041. PMID 12140778. 
  8. ^ Reif A, Herterich S, Strobel A, Ehlis AC, Saur D, Jacob CP, Wienker T, Töpner T, Fritzen S, Walter U, Schmitt A, Fallgatter AJ, Lesch KP (March 2006). "A neuronal nitric oxide synthase (NOS-I) haplotype associated with schizophrenia modifies prefrontal cortex function". Mol. Psychiatry 11 (3): 286–300. doi:10.1038/sj.mp.4001779. PMID 16389274. 
  9. ^ Winkelmann J, Lichtner P, Schormair B, Uhr M, Hauk S, Stiasny-Kolster K, Trenkwalder C, Paulus W, Peglau I, Eisensehr I, Illig T, Wichmann HE, Pfister H, Golic J, Bettecken T, Pütz B, Holsboer F, Meitinger T, Müller-Myhsok B (February 2008). "Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome". Mov. Disord. 23 (3): 350–8. doi:10.1002/mds.21647. PMID 18058820. 
  10. ^ Buttenschön HN, Mors O, Ewald H, McQuillin A, Kalsi G, Lawrence J, Gurling H, Kruse TA (January 2004). "No association between a neuronal nitric oxide synthase (NOS1) gene polymorphism on chromosome 12q24 and bipolar disorder". Am. J. Med. Genet. B Neuropsychiatr. Genet. 124B (1): 73–5. doi:10.1002/ajmg.b.20040. PMID 14681919. 
  11. ^ Steenackers W, De Herdt E, De Boever P, Bos I, Int Panis L (2013). "Neuroinflammation induced by air pollution: gene expression analysis in laboratory animals". Master thesis, GROUP T – Leuven Engineering College. 
  12. ^ a b Jaffrey, S R; Snowman A M; Eliasson M J; Cohen N A; Snyder S H (January 1998). "CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95". Neuron (UNITED STATES) 20 (1): 115–24. doi:10.1016/S0896-6273(00)80439-0. ISSN 0896-6273. PMID 9459447. 
  13. ^ Brenman, J E; Chao D S, Gee S H, McGee A W, Craven S E, Santillano D R, Wu Z, Huang F, Xia H, Peters M F, Froehner S C, Bredt D S (March 1996). "Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains". Cell (UNITED STATES) 84 (5): 757–67. doi:10.1016/S0092-8674(00)81053-3. ISSN 0092-8674. PMID 8625413. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.