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Nitric oxide synthase 1 (neuronal) adaptor protein
Symbols NOS1AP ; 6330408P19Rik; CAPON
External IDs OMIM605551 MGI1917979 HomoloGene40976 GeneCards: NOS1AP Gene
RNA expression pattern
PBB GE NOS1AP 215153 at tn.png
More reference expression data
Species Human Mouse
Entrez 9722 70729
Ensembl ENSG00000198929 ENSMUSG00000038473
UniProt O75052 Q9D3A8
RefSeq (mRNA) NM_001126060 NM_001109985
RefSeq (protein) NP_001119532 NP_001103455
Location (UCSC) Chr 1:
162.04 – 162.35 Mb
Chr 1:
170.3 – 170.59 Mb
PubMed search [1] [2]

Nitric oxide synthase 1 adaptor protein (NOS1AP) also known as carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (CAPON) is a protein that in humans is encoded by the NOS1AP gene.[1][2][3]

This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins.[3] NOS1AP polymorphisms has been associated with the QT interval length.[4]


NOS1AP has been shown to interact with:


  1. ^ Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Feb 1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484. 
  2. ^ a b Jaffrey SR, Snowman AM, Eliasson MJ, Cohen NA, Snyder SH (Mar 1998). "CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95". Neuron 20 (1): 115–24. doi:10.1016/S0896-6273(00)80439-0. PMID 9459447. 
  3. ^ a b "Entrez Gene: NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein". 
  4. ^ Arking DE, Pfeufer A, Post W, et al. (2006). "A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization". Nat. Genet. 38 (6): 644–51. doi:10.1038/ng1790. PMID 16648850. 
  5. ^ a b Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J (August 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". J. Biol. Chem. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173. 
  6. ^ Fang M, Jaffrey SR, Sawa A, Ye K, Luo X, Snyder SH (October 2000). "Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON". Neuron 28 (1): 183–93. doi:10.1016/S0896-6273(00)00095-7. PMID 11086993. 
  7. ^ Jaffrey SR, Benfenati F, Snowman AM, Czernik AJ, Snyder SH (March 2002). "Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 3199–204. doi:10.1073/pnas.261705799. PMC 122496. PMID 11867766. 

Further reading[edit]