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Symbols NPTN ; GP55; GP65; SDFR1; SDR1; np55; np65
External IDs OMIM612820 HomoloGene7531 GeneCards: NPTN Gene
RNA expression pattern
PBB GE NPTN 202228 s at tn.png
More reference expression data
Species Human Mouse
Entrez 27020 n/a
Ensembl ENSG00000156642 n/a
UniProt Q9Y639 n/a
RefSeq (mRNA) NM_001161363 n/a
RefSeq (protein) NP_001154835 n/a
Location (UCSC) Chr 15:
73.85 – 73.93 Mb
PubMed search [1] n/a

Neuroplastin is a protein that in humans is encoded by the NPTN gene.[1][2][3]

Neuroplastin is a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. The alpha and beta transcripts show differential localization within the brain.[3]

In 2014, in a study led by Dr. Sylvane Desrivières, of King's College London's Institute of Psychiatry found that "teenagers who had a highly functioning NPTN gene performed better in intelligence tests"[4][5][6]


  1. ^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  2. ^ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. 
  3. ^ a b "Entrez Gene: NPTN neuroplastin". 
  4. ^ Is intelligence written in the genes?
  5. ^ Researchers Find Gene that Links Grey Matter with Intelligence
  6. ^ Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents

Further reading[edit]