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Neuronal pentraxin II
Symbols NPTX2 ; NARP; NP-II; NP2
External IDs OMIM600750 MGI1858209 HomoloGene1892 GeneCards: NPTX2 Gene
RNA expression pattern
PBB GE NPTX2 213479 at tn.png
More reference expression data
Species Human Mouse
Entrez 4885 53324
Ensembl ENSG00000106236 ENSMUSG00000059991
UniProt P47972 O70340
RefSeq (mRNA) NM_002523 NM_016789
RefSeq (protein) NP_002514 NP_058069
Location (UCSC) Chr 7:
98.25 – 98.26 Mb
Chr 5:
144.55 – 144.56 Mb
PubMed search [1] [2]

Neuronal pentraxin-2 is a protein that in humans is encoded by the NPTX2 gene.[1][2]


This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells.[2]

Clinical significance[edit]

Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD.[2]


  1. ^ Hsu YC, Perin MS (Feb 1996). "Human neuronal pentraxin II (NPTX2): conservation, genomic structure, and chromosomal localization". Genomics 28 (2): 220–7. doi:10.1006/geno.1995.1134. PMID 8530029. 
  2. ^ a b c "Entrez Gene: NPTX2 neuronal pentraxin II". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.