NPTX2

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Neuronal pentraxin II
Identifiers
Symbols NPTX2 ; NARP; NP-II; NP2
External IDs OMIM600750 MGI1858209 HomoloGene1892 GeneCards: NPTX2 Gene
RNA expression pattern
PBB GE NPTX2 213479 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4885 53324
Ensembl ENSG00000106236 ENSMUSG00000059991
UniProt P47972 O70340
RefSeq (mRNA) NM_002523 NM_016789
RefSeq (protein) NP_002514 NP_058069
Location (UCSC) Chr 7:
98.25 – 98.26 Mb
Chr 5:
144.55 – 144.56 Mb
PubMed search [1] [2]

Neuronal pentraxin-2 is a protein that in humans is encoded by the NPTX2 gene.[1][2]

Function[edit]

This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells.[2]

Clinical significance[edit]

Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD.[2]

References[edit]

  1. ^ Hsu YC, Perin MS (Feb 1996). "Human neuronal pentraxin II (NPTX2): conservation, genomic structure, and chromosomal localization". Genomics 28 (2): 220–7. doi:10.1006/geno.1995.1134. PMID 8530029. 
  2. ^ a b c "Entrez Gene: NPTX2 neuronal pentraxin II". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.