NAD(P)H dehydrogenase (quinone 1)

From Wikipedia, the free encyclopedia
  (Redirected from NQO1)
Jump to: navigation, search
NAD(P)H dehydrogenase, quinone 1
Protein NQO1 PDB 1d4a.png
PDB rendering based on 1d4a.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NQO1 ; DHQU; DIA4; DTD; NMOR1; NMORI; QR1
External IDs OMIM125860 MGI103187 HomoloGene695 ChEMBL: 3623 GeneCards: NQO1 Gene
EC number 1.6.5.2
RNA expression pattern
PBB GE NQO1 201468 s at tn.png
PBB GE NQO1 201467 s at tn.png
PBB GE NQO1 210519 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1728 18104
Ensembl ENSG00000181019 ENSMUSG00000003849
UniProt P15559 Q64669
RefSeq (mRNA) NM_000903 NM_008706
RefSeq (protein) NP_000894 NP_032732
Location (UCSC) Chr 16:
69.74 – 69.76 Mb
Chr 8:
107.39 – 107.4 Mb
PubMed search [1] [2]

NAD(P)H dehydrogenase [quinone] 1 is an enzyme that in humans is encoded by the NQO1 gene.[1]

This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2] Recent pharmacological research suggests feasibility of genotype-directed redox chemotherapeutic intervention targeting NQO1*2 breast cancer, a common missense genotype encoding a functionally impaired NQO1 protein.[3]

Interactions[edit]

NAD(P)H dehydrogenase (quinone 1) has been shown to interact with HSPA4.[4]

References[edit]

  1. ^ Jaiswal AK, McBride OW, Adesnik M, Nebert DW (October 1988). "Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16". J Biol Chem 263 (27): 13572–8. PMID 2843525. 
  2. ^ "Entrez Gene: NQO1 NAD(P)H dehydrogenase, quinone 1". 
  3. ^ Cabello CM, Lamore SD, Bair WB, Davis AL, Azimian SM, Wondrak GT (November [Epub ahead of print] 2010). "DCPIP (2,6-dichlorophenolindophenol) as a genotype-directed redox chemotherapeutic targeting NQO1*2 breast carcinoma.". Free Radic Res. 45 (3): 276–292. doi:10.3109/10715762.2010.526766. PMID 21034357. 
  4. ^ Anwar, Adil; Siegel David; Kepa Jadwiga K; Ross David (April 2002). "Interaction of the molecular chaperone Hsp70 with human NAD(P)H:quinone oxidoreductase 1". J. Biol. Chem. (United States) 277 (16): 14060–7. doi:10.1074/jbc.M111576200. ISSN 0021-9258. PMID 11821413. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.