From Wikipedia, the free encyclopedia
Jump to: navigation, search
For the stimulant, see NRG-3.
Neuregulin 3
Symbols NRG3 ; HRG3; pro-NRG3
External IDs OMIM605533 MGI1097165 HomoloGene32051 GeneCards: NRG3 Gene
Species Human Mouse
Entrez 10718 18183
Ensembl ENSG00000185737 ENSMUSG00000041014
UniProt P56975 O35181
RefSeq (mRNA) NM_001010848 NM_001190187
RefSeq (protein) NP_001010848 NP_001177116
Location (UCSC) Chr 10:
83.64 – 84.75 Mb
Chr 14:
38.37 – 39.47 Mb
PubMed search [1] [2]

Neuregulin 3 also known as NRG3 is a member of the neuregulin protein family which in humans is encoded by the NRG3 gene.[1][2]


NRG3 can bind to the extracellular domain of the ERBB4 receptor tyrosine kinase but not to the related family members ERBB2 or ERBB3. NRG3 binding stimulates tyrosine phosphorylation of ERBB4.[2]

Clinical significance[edit]

Variants of the NRG3 gene have been linked to a susceptibility to schizophrenia.[3]

It has also been linked to Hirschsprung's disease.[4]


  1. ^ "Entrez Gene: NRG3 neuregulin 3". 
  2. ^ a b Zhang D, Sliwkowski MX, Mark M, Frantz G, Akita R, Sun Y, Hillan K, Crowley C, Brush J, Godowski PJ (September 1997). "Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9562–7. doi:10.1073/pnas.94.18.9562. PMC 23218. PMID 9275162. 
  3. ^ Chen PL, Avramopoulos D, Lasseter VK, McGrath JA, Fallin MD, Liang KY, Nestadt G, Feng N, Steel G, Cutting AS, Wolyniec P, Pulver AE, Valle D (January 2009). "Fine mapping on chromosome 10q22-q23 implicates Neuregulin 3 in schizophrenia". Am. J. Hum. Genet. 84 (1): 21–34. doi:10.1016/j.ajhg.2008.12.00. PMC 2668048. PMID 19118813. Lay summaryThe Johns Hopkins News-Letter. 
  4. ^ Yang J, Duan S, Zhong R, Yin J, Pu J, Ke J, Lu X, Zou L, Zhang H, Zhu Z, Wang D, Xiao H, Guo A, Xia J, Miao X, Tang S, Wang G (January 2013). "Exome Sequencing Identified NRG3 as a Novel Susceptible Gene of Hirschsprung's Disease in a Chinese Population". Mol. Neurobiol. 47: 957–966. doi:10.1007/s12035-012-8392-4. PMID 23315268. 

Further reading[edit]