NRXN2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Neurexin 2
Identifiers
Symbols NRXN2 ; FLJ40892; KIAA0921
External IDs OMIM600566 MGI1096362 HomoloGene86984 GeneCards: NRXN2 Gene
RNA expression pattern
PBB GE NRXN2 209982 s at tn.png
PBB GE NRXN2 209983 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9379 18190
Ensembl ENSG00000110076 ENSMUSG00000033768
UniProt P58401 E9PUM9
RefSeq (mRNA) NM_015080 NM_001205234
RefSeq (protein) NP_055895 NP_001192163
Location (UCSC) Chr 11:
64.37 – 64.49 Mb
Chr 19:
6.42 – 6.54 Mb
PubMed search [1] [2]

Neurexin-2-alpha is a protein that in humans is encoded by the NRXN2 gene.[1][2]

Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins.[2]

References[edit]

  1. ^ Ushkaryov YA, Petrenko AG, Geppert M, Sudhof TC (Aug 1992). "Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin". Science 257 (5066): 50–56. doi:10.1126/science.1621094. PMID 1621094. 
  2. ^ a b "Entrez Gene: NRXN2 neurexin 2". 

Further reading[edit]