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5'-nucleotidase, cytosolic IIIA
Protein NT5C3 PDB 2bdu.png
PDB rendering based on 2bdu.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NT5C3A ; NT5C3; P5'N-1; P5N-1; PN-I; POMP; PSN1; UMPH; UMPH1; cN-III; hUMP1; p36
External IDs OMIM606224 MGI1927186 HomoloGene9534 IUPHAR: 1237 GeneCards: NT5C3A Gene
EC number
Species Human Mouse
Entrez 51251 107569
Ensembl ENSG00000122643 ENSMUSG00000029780
UniProt Q9H0P0 Q9D020
RefSeq (mRNA) NM_001002009 NM_001252374
RefSeq (protein) NP_001002009 NP_001239303
Location (UCSC) Chr 7:
33.05 – 33.1 Mb
Chr 6:
56.88 – 56.92 Mb
PubMed search [1] [2]

Cytosolic 5'-nucleotidase 3 is an enzyme that in humans is encoded by the NT5C3 gene.[1][2][3]

Pyrimidine 5-prime-nucleotidase (P5N; EC, also called uridine 5-prime monophosphate hydrolase (UMPH), catalyzes the dephosphorylation of the pyrimidine 5-prime monophosphates UMP and CMP to the corresponding nucleosides. There are 2 isozymes of pyrimidine 5-prime nucleotidase in red blood cells, referred to as type I (UMPH1) and type II (UMPH2; MIM 191720). The 2 enzymes are not separable by electrophoresis in humans but have distinct kinetic properties, and the proteins show no homology.[supplied by OMIM][3]


  1. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152. 
  2. ^ Amici A, Emanuelli M, Raffaelli N, Ruggieri S, Saccucci F, Magni G (Sep 2000). "Human erythrocyte pyrimidine 5-nucleotidase, PN-I, is identical to p36, a protein associated to lupus inclusion formation in response to alpha-interferon". Blood 96 (4): 1596–8. PMID 10942414. 
  3. ^ a b "Entrez Gene: NT5C3 5'-nucleotidase, cytosolic III". 

Further reading[edit]