Pyrimidine 5-prime-nucleotidase (P5N; EC 184.108.40.206), also called uridine 5-prime monophosphate hydrolase (UMPH), catalyzes the dephosphorylation of the pyrimidine 5-prime monophosphates UMP and CMP to the corresponding nucleosides. There are 2 isozymes of pyrimidine 5-prime nucleotidase in red blood cells, referred to as type I (UMPH1) and type II (UMPH2; MIM 191720). The 2 enzymes are not separable by electrophoresis in humans but have distinct kinetic properties, and the proteins show no homology.[supplied by OMIM]
^Amici A, Emanuelli M, Raffaelli N, Ruggieri S, Saccucci F, Magni G (Sep 2000). "Human erythrocyte pyrimidine 5-nucleotidase, PN-I, is identical to p36, a protein associated to lupus inclusion formation in response to alpha-interferon". Blood96 (4): 1596–8. PMID10942414.
Rich SA, Bose M, Tempst P, Rudofsky UH (1996). "Purification, microsequencing, and immunolocalization of p36, a new interferon-alpha-induced protein that is associated with human lupus inclusions". J. Biol. Chem.271 (2): 1118–26. doi:10.1074/jbc.271.2.1118. PMID8557639.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res.6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID8889549.
Amici A, Emanuelli M, Magni G, et al. (1998). "Pyrimidine nucleotidases from human erythrocyte possess phosphotransferase activities specific for pyrimidine nucleotides". FEBS Lett.419 (2–3): 263–7. doi:10.1016/S0014-5793(97)01464-6. PMID9428647.
Balta G, Gumruk F, Akarsu N, et al. (2003). "Molecular characterization of Turkish patients with pyrimidine 5' nucleotidase-I deficiency". Blood102 (5): 1900–3. doi:10.1182/blood-2003-02-0628. PMID12714505.
Bianchi P, Fermo E, Alfinito F, et al. (2003). "Molecular characterization of six unrelated Italian patients affected by pyrimidine 5'-nucleotidase deficiency". Br. J. Haematol.122 (5): 847–51. doi:10.1046/j.1365-2141.2003.04532.x. PMID12930399.