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Netrin 1
Symbols NTN1 ; NTN1L
External IDs OMIM601614 MGI105088 HomoloGene21008 ChEMBL: 1741307 GeneCards: NTN1 Gene
RNA expression pattern
PBB GE NTN1 208005 at tn.png
More reference expression data
Species Human Mouse
Entrez 9423 18208
Ensembl ENSG00000065320 ENSMUSG00000020902
UniProt O95631 O09118
RefSeq (mRNA) NM_004822 NM_008744
RefSeq (protein) NP_004813 NP_032770
Location (UCSC) Chr 17:
8.92 – 9.15 Mb
Chr 11:
68.21 – 68.4 Mb
PubMed search [1] [2]

Netrin-1 is a protein that in humans is encoded by the NTN1 gene.[1][2]

Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development.[2]


NTN1 has been shown to interact with Deleted in Colorectal Cancer.[1][3]


  1. ^ a b Meyerhardt JA, Caca K, Eckstrand BC, Hu G, Lengauer C, Banavali S, Look AT, Fearon ER (Apr 1999). "Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas". Cell Growth Differ 10 (1): 35–42. PMID 9950216. 
  2. ^ a b "Entrez Gene: NTN1 netrin 1". 
  3. ^ Geisbrecht, Brian V; Dowd Kimberly A; Barfield Ronald W; Longo Patti A; Leahy Daniel J (Aug 2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". J. Biol. Chem. (United States) 278 (35): 32561–8. doi:10.1074/jbc.M302943200. ISSN 0021-9258. PMID 12810718. 

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