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NUAK family, SNF1-like kinase, 1
Symbols NUAK1 ; ARK5
External IDs OMIM608130 MGI1925226 HomoloGene8896 IUPHAR: 2129 ChEMBL: 5784 GeneCards: NUAK1 Gene
EC number
Species Human Mouse
Entrez 9891 77976
Ensembl ENSG00000074590 ENSMUSG00000020032
UniProt O60285 Q641K5
RefSeq (mRNA) NM_014840 NM_001004363
RefSeq (protein) NP_055655 NP_001004363
Location (UCSC) Chr 12:
106.46 – 106.53 Mb
Chr 10:
84.37 – 84.44 Mb
PubMed search [1] [2]

NUAK family SNF1-like kinase 1 also known as AMPK-related protein kinase 5 (ARK5) is an enzyme that in humans is encoded by the NUAK1 gene.[1][2][3]


NUAK1 has been shown to interact with USP9X[4] and Ubiquitin C.[4]


  1. ^ Suzuki A, Kusakai G, Kishimoto A, Lu J, Ogura T, Lavin MF, Esumi H (Dec 2002). "Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein". J Biol Chem 278 (1): 48–53. doi:10.1074/jbc.M206025200. PMID 12409306. 
  2. ^ Suzuki A, Kusakai G, Kishimoto A, Lu J, Ogura T, Esumi H (Sep 2003). "ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents or UV irradiation". Oncogene 22 (40): 6177–82. doi:10.1038/sj.onc.1206899. PMID 13679856. 
  3. ^ "Entrez Gene: NUAK1 NUAK family, SNF1-like kinase, 1". 
  4. ^ a b Al-Hakim, Abdallah K; Zagorska Anna; Chapman Louise; Deak Maria; Peggie Mark; Alessi Dario R (Apr 2008). "Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains". Biochem. J. (England) 411 (2): 249–60. doi:10.1042/BJ20080067. PMID 18254724. 

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