NUCB1

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Nucleobindin 1
Protein NUCB1 PDB 1snl.png
PDB rendering based on 1snl.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NUCB1 ; CALNUC; NUC
External IDs OMIM601323 MGI97388 HomoloGene4507 GeneCards: NUCB1 Gene
RNA expression pattern
PBB GE NUCB1 200649 at tn.png
PBB GE NUCB1 200646 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4924 18220
Ensembl ENSG00000104805 ENSMUSG00000030824
UniProt Q02818 Q02819
RefSeq (mRNA) NM_006184 NM_001163662
RefSeq (protein) NP_006175 NP_001157134
Location (UCSC) Chr 19:
49.4 – 49.43 Mb
Chr 7:
45.49 – 45.51 Mb
PubMed search [1] [2]

Nucleobindin-1 (NUCB1), also known as calnuc, is a protein that in humans is encoded by the NUCB1 gene.[1][2]

Structure[edit]

The human calnuc protein contains 461 amino acids and has a pI of 4.9.[3]

The protein contains the following regions and domains:

References[edit]

  1. ^ Miura K, Hirai M, Kanai Y, Kurosawa Y (Feb 1997). "Organization of the human gene for nucleobindin (NUC) and its chromosomal assignment to 19q13.2-q13.4". Genomics 34 (2): 181–6. doi:10.1006/geno.1996.0263. PMID 8661046. 
  2. ^ "Entrez Gene: NUCB1 nucleobindin 1". 
  3. ^ a b Lin P, Le-Niculescu H, Hofmeister R, McCaffery JM, Jin M, Hennemann H, McQuistan T, De Vries L, Farquhar MG (June 1998). "The mammalian calcium-binding protein, nucleobindin (CALNUC), is a Golgi resident protein". J. Cell Biol. 141 (7): 1515–27. doi:10.1083/jcb.141.7.1515. PMC 2132997. PMID 9647645. 
  4. ^ a b Miura K, Titani K, Kurosawa Y, Kanai Y (August 1992). "Molecular cloning of nucleobindin, a novel DNA-binding protein that contains both a signal peptide and a leucine zipper structure". Biochem. Biophys. Res. Commun. 187 (1): 375–80. doi:10.1016/S0006-291X(05)81503-7. PMID 1520323. 
  5. ^ Kanuru M, Raman R, Aradhyam GK (January 2013). "Serine protease activity of calnuc: regulation by Zn2+ and G proteins". J. Biol. Chem. 288 (3): 1762–73. doi:10.1074/jbc.M112.382846. PMID 23195954. 

Further reading[edit]