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Nucleobindin 2
Symbols NUCB2 ; NEFA
External IDs OMIM608020 MGI1858179 HomoloGene3676 GeneCards: NUCB2 Gene
RNA expression pattern
PBB GE NUCB2 203675 at tn.png
More reference expression data
Species Human Mouse
Entrez 4925 53322
Ensembl ENSG00000070081 ENSMUSG00000030659
UniProt P80303 P81117
RefSeq (mRNA) NM_005013 NM_001130479
RefSeq (protein) NP_005004 NP_001123951
Location (UCSC) Chr 11:
17.23 – 17.37 Mb
Chr 7:
116.5 – 116.54 Mb
PubMed search [1] [2]

Nucleobindin-2 is a protein that in humans is encoded by the NUCB2 gene.[1][2]

Nucleobindin-2 is a calcium-binding EF-hand protein.[supplied by OMIM][2]


NUCB2 has been shown to interact with NDN.[3]


  1. ^ Barnikol-Watanabe S, Gross NA, Gotz H, Henkel T, Karabinos A, Kratzin H, Barnikol HU, Hilschmann N (February 1995). "Human protein NEFA, a novel DNA binding/EF-hand/leucine zipper protein. Molecular cloning and sequence analysis of the cDNA, isolation and characterization of the protein". Biol Chem Hoppe Seyler 375 (8): 497–512. doi:10.1515/bchm3.1994.375.8.497. PMID 7811391. 
  2. ^ a b "Entrez Gene: NUCB2 nucleobindin 2". 
  3. ^ Taniguchi, N; Taniura H; Niinobe M; Takayama C; Tominaga-Yoshino K; Ogura A; Yoshikawa K (October 2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". J. Biol. Chem. (UNITED STATES) 275 (41): 31674–81. doi:10.1074/jbc.M005103200. ISSN 0021-9258. PMID 10915798. 

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