NUDT9

Nudix (nucleoside diphosphate linked moiety X)-type motif 9
PDB rendering based on 1q33.
Available structures PDB 1Q33, 1QVJ
Identifiers
Symbols	NUDT9; MGC3037; NUDT10
External IDs	OMIM: 606022 MGI: 1921417 HomoloGene: 11435 GeneCards: NUDT9 Gene
EC number	3.6.1.13
Gene Ontology Molecular function • hydrolase activity • ADP-sugar diphosphatase activity • adenosine-diphosphatase activity • ADP-ribose diphosphatase activity Cellular component • intracellular • mitochondrion Biological process • ADP catabolic process • IDP catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	53343	74167
Ensembl	ENSG00000170502	ENSMUSG00000029310
UniProt	Q9BW91	n/a
RefSeq (mRNA)	NM_024047.3	NM_028794.3
RefSeq (protein)	NP_076952.1	NP_083070.2
Location (UCSC)	Chr 4: 88.34 – 88.38 Mb	Chr 5: 104.48 – 104.49 Mb
PubMed search	[1]	[2]

ADP-ribose pyrophosphatase, mitochondrial is an enzyme that in humans is encoded by the NUDT9 gene.

Further reading

• Lin S, Gasmi L, Xie Y et al (2002). "Cloning, expression and characterisation of a human Nudix hydrolase specific for adenosine 5'-diphosphoribose (ADP-ribose)". Biochim. Biophys. Acta 1594 (1): 127–35. doi:10.1016/S0167-4838(01)00296-5. PMID 11825615. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Zhang HT, Yan ZQ, Hu XB et al (2004). "Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9 detected via yeast two-hybrid method". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35 (8): 747–51. PMID 12897971. 
• Shen BW, Perraud AL, Scharenberg A, Stoddard BL (2003). "The crystal structure and mutational analysis of human NUDT9". J. Mol. Biol. 332 (2): 385–98. doi:10.1016/S0022-2836(03)00954-9. PMID 12948489. 
• Clark HF, Gurney AL, Abaya E et al (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697. 
• Ota T, Suzuki Y, Nishikawa T et al (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA et al (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Otsuki T, Ota T, Nishikawa T et al (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743. 
• Carloto A, Costas MJ, Cameselle JC et al (2006). "The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2". Biochim. Biophys. Acta 1760 (10): 1545–51. doi:10.1016/j.bbagen.2006.06.003. PMID 16860484.