NUP153, is a human gene that codes for the 153 kDa protein Nucleoporin 153kDa.
Nuclear pore complexes are extremely elaborate structures that mediate the regulated movement of macromolecules between the nucleus and cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are pore complex-specific glycoproteins characterized by cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. The protein encoded by this gene has three distinct domains: a N-terminal region within which a pore targeting domain has been identified, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats.
^Kehlenbach, R H; Gerace L (June 2000). "Phosphorylation of the nuclear transport machinery down-regulates nuclear protein import in vitro". J. Biol. Chem. (UNITED STATES) 275 (23): 17848–56. doi:10.1074/jbc.M001455200. ISSN0021-9258. PMID10749866.Cite uses deprecated parameters (help)
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Kehlenbach RH, Gerace L (2000). "Phosphorylation of the nuclear transport machinery down-regulates nuclear protein import in vitro.". J. Biol. Chem.275 (23): 17848–56. doi:10.1074/jbc.M001455200. PMID10749866.
Kutay U, Hartmann E, Treichel N, et al. (2001). "Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily.". J. Biol. Chem.275 (51): 40163–8. doi:10.1074/jbc.M006242200. PMID11024021.
Dimaano C, Ball JR, Prunuske AJ, Ullman KS (2002). "RNA association defines a functionally conserved domain in the nuclear pore protein Nup153.". J. Biol. Chem.276 (48): 45349–57. doi:10.1074/jbc.M102592200. PMID11567018.