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Nucleoporin 153kDa
Protein NUP153 PDB 2gqe.png
PDB rendering based on 2gqe.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NUP153 ; HNUP153; N153
External IDs OMIM603948 MGI2385621 HomoloGene68442 GeneCards: NUP153 Gene
RNA expression pattern
PBB GE NUP153 202097 at tn.png
More reference expression data
Species Human Mouse
Entrez 9972 218210
Ensembl ENSG00000124789 ENSMUSG00000021374
UniProt P49790 E9Q3G8
RefSeq (mRNA) NM_001278209 NM_175749
RefSeq (protein) NP_001265138 NP_786925
Location (UCSC) Chr 6:
17.62 – 17.71 Mb
Chr 13:
46.68 – 46.73 Mb
PubMed search [1] [2]

NUP153, is a human gene that codes for the 153 kDa protein Nucleoporin 153kDa.

Nuclear pore complexes are extremely elaborate structures that mediate the regulated movement of macromolecules between the nucleus and cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are pore complex-specific glycoproteins characterized by cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. The protein encoded by this gene has three distinct domains: a N-terminal region within which a pore targeting domain has been identified, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats.[1]


NUP153 has been shown to interact with SENP2[2][3] and KPNB1.[4][5][6]


  1. ^ "Entrez Gene: NUP153 nucleoporin 153kDa". 
  2. ^ Hang, Jun; Dasso Mary (May 2002). "Association of the human SUMO-1 protease SENP2 with the nuclear pore". J. Biol. Chem. (United States) 277 (22): 19961–6. doi:10.1074/jbc.M201799200. ISSN 0021-9258. PMID 11896061. 
  3. ^ Zhang, Hong; Saitoh Hisato; Matunis Michael J (September 2002). "Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex". Mol. Cell. Biol. (United States) 22 (18): 6498–508. doi:10.1128/MCB.22.18.6498-6508.2002. ISSN 0270-7306. PMC 135644. PMID 12192048. 
  4. ^ Nakielny, S; Shaikh S; Burke B; Dreyfuss G (April 1999). "Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain". EMBO J. (ENGLAND) 18 (7): 1982–95. doi:10.1093/emboj/18.7.1982. ISSN 0261-4189. PMC 1171283. PMID 10202161. 
  5. ^ Kehlenbach, R H; Gerace L (June 2000). "Phosphorylation of the nuclear transport machinery down-regulates nuclear protein import in vitro". J. Biol. Chem. (UNITED STATES) 275 (23): 17848–56. doi:10.1074/jbc.M001455200. ISSN 0021-9258. PMID 10749866. 
  6. ^ Ben-Efraim, I; Gerace L (January 2001). "Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import". J. Cell Biol. (United States) 152 (2): 411–7. doi:10.1083/jcb.152.2.411. ISSN 0021-9525. PMC 2199621. PMID 11266456. 

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