Nucleoporin 214

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Nucleoporin 214kDa
Protein NUP214 PDB 2oit.png
PDB rendering based on 2oit.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NUP214 ; CAIN; CAN; D9S46E; N214; p250
External IDs OMIM114350 MGI1095411 HomoloGene38008 GeneCards: NUP214 Gene
RNA expression pattern
PBB GE NUP214 202155 s at tn.png
PBB GE NUP214 211261 at tn.png
More reference expression data
Species Human Mouse
Entrez 8021 227720
Ensembl ENSG00000126883 ENSMUSG00000001855
UniProt P35658 Q80U93
RefSeq (mRNA) NM_005085 NM_172268
RefSeq (protein) NP_005076 NP_758472
Location (UCSC) Chr 9:
134 – 134.11 Mb
Chr 2:
31.97 – 32.05 Mb
PubMed search [1] [2]

Nucleoporin 214 (Nup2014) is a protein that in humans is encoded by the NUP214 gene.[1][2][3]

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome.[3]


NUP214 has been shown to interact with NXF2,[4] ZFP36[5] and NXF1.[4][6]


  1. ^ Kraemer D, Wozniak RW, Blobel G, Radu A (March 1994). "The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm". Proc Natl Acad Sci U S A 91 (4): 1519–23. doi:10.1073/pnas.91.4.1519. PMC 43191. PMID 8108440. 
  2. ^ von Lindern M, Poustka A, Lerach H, Grosveld G (August 1990). "The (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of a target gene on 9q34". Mol Cell Biol 10 (8): 4016–26. PMC 360912. PMID 2370860. 
  3. ^ a b "Entrez Gene: NUP214 nucleoporin 214kDa". 
  4. ^ a b Herold, A; Suyama M; Rodrigues J P; Braun I C; Kutay U; Carmo-Fonseca M; Bork P; Izaurralde E (December 2000). "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture". Mol. Cell. Biol. (UNITED STATES) 20 (23): 8996–9008. doi:10.1128/MCB.20.23.8996-9008.2000. ISSN 0270-7306. PMC 86553. PMID 11073998. 
  5. ^ Carman, Julie A; Nadler Steven G (March 2004). "Direct association of tristetraprolin with the nucleoporin CAN/Nup214". Biochem. Biophys. Res. Commun. (United States) 315 (2): 445–9. doi:10.1016/j.bbrc.2004.01.080. ISSN 0006-291X. PMID 14766228. 
  6. ^ Schmitt, I; Gerace L (November 2001). "In vitro analysis of nuclear transport mediated by the C-terminal shuttle domain of Tap". J. Biol. Chem. (United States) 276 (45): 42355–63. doi:10.1074/jbc.M103916200. ISSN 0021-9258. PMID 11551912. 

Further reading[edit]