Nucleoporin 50

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Nucleoporin 50kDa
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols NUP50 ; NPAP60; NPAP60L
External IDs OMIM604646 MGI1351502 HomoloGene5190 GeneCards: NUP50 Gene
RNA expression pattern
PBB GE NUP50 218294 s at tn.png
PBB GE NUP50 213682 at tn.png
PBB GE NUP50 218293 x at tn.png
More reference expression data
Species Human Mouse
Entrez 10762 18141
Ensembl ENSG00000093000 ENSMUSG00000016619
UniProt Q9UKX7 Q9JIH2
RefSeq (mRNA) NM_007172 NM_016714
RefSeq (protein) NP_009103 NP_057923
Location (UCSC) Chr 22:
45.56 – 45.58 Mb
Chr 15:
84.92 – 84.94 Mb
PubMed search [1] [2]

Nucleoporin 50 (Nup50) is a protein that in humans is encoded by the NUP50 gene.[1][2]

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene.[2]


NUP50 has been shown to interact with KPNB1[3] and CDKN1B.[4]


  1. ^ Trichet V, Shkolny D, Dunham I, Beare D, McDermid HE (October 1999). "Mapping and complex expression pattern of the human NPAP60L nucleoporin gene". Cytogenet Cell Genet 85 (3–4): 221–6. doi:10.1159/000015297. PMID 10449902. 
  2. ^ a b "Entrez Gene: NUP50 nucleoporin 50kDa". 
  3. ^ Lindsay, Mark E; Plafker Kendra; Smith Alicia E; Clurman Bruce E; Macara Ian G (August 2002). "Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import". Cell (United States) 110 (3): 349–60. doi:10.1016/S0092-8674(02)00836-X. ISSN 0092-8674. PMID 12176322. 
  4. ^ Smitherman, M; Lee K; Swanger J; Kapur R; Clurman B E (August 2000). "Characterization and Targeted Disruption of Murine Nup50, a p27Kip1-Interacting Component of the Nuclear Pore Complex". Mol. Cell. Biol. (UNITED STATES) 20 (15): 5631–42. doi:10.1128/MCB.20.15.5631-5642.2000. ISSN 0270-7306. PMC 86029. PMID 10891500. 

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